General Principle for Fabricating Natural Globular Protein-Based Double-Network Hydrogels with Integrated Highly Mechanical Properties and Surface Adhesion on Solid Surfaces

Tang, Ziqing; Chen, Qiang; Chen, Feng; Zhu, Lin; Lu, Shaoping; Ren, Baiping; Zhang, Yanxian; Yang, Jia; Zheng, Jie

doi:10.1021/acs.chemmater.8b03860

Cited by 110 publications

(70 citation statements)

References 52 publications

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“…To characterize the mechano‐optical properties of the hydrogel with complex ordered structures, we improved the mechanical properties of the physical gel based on the double‐network (DN) principle . After being swelled in a precursor solution, a loosely cross‐linked polyacrylamide (PAAm) network was formed within the preformed anisotropic hydrogel by photopolymerization . The resultant PBDT/PAAm DN hydrogel showed good mechanical performances, with tensile breaking stress of 120 ± 15 kPa, breaking strain of 225 ± 20%, and Young's modulus of 160 ± 29 kPa ( Figure a).…”

Section: Resultsmentioning

confidence: 99%

Programmed Diffusion Induces Anisotropic Superstructures in Hydrogels with High Mechano‐Optical Sensitivity

Qiao

Gong

et al. 2019

Adv Materials Technologies

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including low sliding friction and strong bonding to the bone. [2,3] In contrast, synthetic hydrogels usually have an isotropic and amorphous structure, resulting in the absence of anisotropic optical and mechanical properties. Inspired by the nature, there are many efforts to develop anisotropic hydrogels by different strategies, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] including molecular self-assembly, [5,6] electric/magnetic field-directed orientation, [7][8][9][10][11][12][13][14] and diffusion-induced orientation, [15][16][17] to form ordered structures before or during the gelation process. For instance, Thomas and co-workers prepared photonic hydrogels by molecular self-assembly of a block copolymer to form a uniform lamellar structure, which was subsequently fixed by chemical cross-linking. [5] The resultant hydrogel showed iridescent colors under different ionic strength owing to the Bragg diffraction of the light with a specific wavelength. Aida, Miyamoto, and their coworkers applied magnetic and electric fields to orient the charged nanosheets followed by in situ polymerization of the precursor solution to fabricate monodomain nanocomposite hydrogels, which showed anisotropic optical and mechanical properties, as well as anisotropic actuation under external stimulations. [7][8][9] Dobashi and co-workers have developed anisotropic physical hydrogels by dialyzing the solution of curdlan or DNA in the solution of multivalent metallic ions, in which the diffusion of ions induced molecular orientation and gelation of the negatively charged, rigid biomacromolecules. [15,16] Although big progress has been achieved in designing monodomain hydrogels, it still remains a big challenge to develop anisotropic gels with intricate ordered structures, because of lacking efficient approach to control the local orientation of molecules or nanoparticles at different regions. Recently, Studart and co-workers fabricated composite hydrogels by multistep polymerization with a magnetic field to orient the nanofillers along a specific direction. [22,23] The integrated hydrogels with complex ordered structures showed programmed deformations under external stimulations. However, the fabrication process was time-consuming because the separate domains with specific orientations should be completed step-wisely to form the composite hydrogel. A facile and efficient strategy is really desired to prepare hydrogels with intricate anisotropic superstructures, which is an important step to develop biomimetic materials with versatile functions. A straightforward idea is to simultaneously modulate the external field with independent Most soft biotissues possess intricate anisotropic superstructures, which afford living organism versatile functionalities. However, it remains a big challenge to develop such complex ordered structures in synthetic hydrogels. Here a simple and efficient strategy to fabricate periodically patterned hydrogels with complex anisotropic structures by diffusion-induced orientation and g...

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Section: Resultsmentioning

confidence: 99%

Programmed Diffusion Induces Anisotropic Superstructures in Hydrogels with High Mechano‐Optical Sensitivity

Qiao

Gong

et al. 2019

Adv Materials Technologies

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“…The use of hydrogel has garnered great attention as a means of improvements in adhesion that leave no residue after detachment. [105,[206][207][208][209][210] Figure 8f shows one example of hydrogels that are very durable and adhesive, inspired by the delaminated structure of the skin. [105] In situ polymerization of nucleobasedriven adhesive hydrogels on the conductive tough hydrogels resulted in robust direct adhesion to the skin as well as various solid materials.…”

Section: Adhesionmentioning

confidence: 99%

Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment

et al. 2019

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glasses, watches, wristbands, or belts, are either fully or partially composed of planar and rigid materials, which require the use of obtrusive, hard supports or additional bendable strips to be mounted on the human body. Therefore, clinical devices that use the existing wearables cause discomfort and limit monitoring of human physiological data in the laboratory. This is the big limitation factor to overcome despite the ever-growing market for wearables in broader screenings outside of the clinic. By this account, it is necessary to replace the bulky and rigid plastics and metal components in the sensors and electronics with skin-like materials for enhanced wearability and functionality.The concept of WFHE poses a possible solution to address the aforementioned difficulties by providing user comfort, compliant mechanics, soft integration, multifunctionality, and smart diagnostics with embedded machine learning algorithms. Specifically, such electronics would provide stable and intimate contact to the soft human skin without adding any mechanical and thermal loadings or causing skin breakdown. Current development strategies and approaches for advanced WFHE focus on soft, flexible form factors, nonirritating and nontoxic characteristics, fully autonomous energy components, seamless wireless communications, Recent advances in soft materials and system integration technologies have provided a unique opportunity to design various types of wearable flexible hybrid electronics (WFHE) for advanced human healthcare and humanmachine interfaces. The hybrid integration of soft and biocompatible materials with miniaturized wireless wearable systems is undoubtedly an attractiveprospect in the sense that the successful device performance requires high degrees of mechanical flexibility, sensing capability, and user-friendly simplicity. Here, the most up-to-date materials, sensors, and system-packaging technologies to develop advanced WFHE are provided. Details of mechanical, electrical, physicochemical, and biocompatible properties are discussed with integrated sensor applications in healthcare, energy, and environment. In addition, limitations of the current materials are discussed, as well as key challenges and the future direction of WFHE. Collectively, an all-inclusive review of the newly developed WFHE along with a summary of imperative requirements of material properties, sensor capabilities, electronics performance, and skin integrations is provided. Wearable Flexible Hybrid ElectronicsThe ORCID identification number(s) for the author(s) of this article can be found under https://doi.

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“…Recently, biocompatible and biodegradable protein hydrogels have been developed to be used as functional biomaterials in the field of therapeutic delivery and tissue engineering. For example, there are synthetic protein based hydrogels which are derived from single protein component such as elastin [ 175 ], collagen [ 176 ], and globular proteins (e.g., bovine serum albumin, ovalbumin and YajC-CT) [ 177 , 235 ]. The main advantages of pure protein hydrogels are relatively homogenous network structure and simple procedure.…”

Section: Biomolecules For Tissue Regenerationmentioning

confidence: 99%

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

et al. 2020

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Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.

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General Principle for Fabricating Natural Globular Protein-Based Double-Network Hydrogels with Integrated Highly Mechanical Properties and Surface Adhesion on Solid Surfaces

Cited by 110 publications

References 52 publications

Programmed Diffusion Induces Anisotropic Superstructures in Hydrogels with High Mechano‐Optical Sensitivity

Programmed Diffusion Induces Anisotropic Superstructures in Hydrogels with High Mechano‐Optical Sensitivity

Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

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