General practice computing in Scotland.

Taylor, Michael W.; Taylor, Ross; Ryan, Margaret; Paterson, N. I. A.; Duncan, Robert E.; Brotherston, K. G.

doi:10.1136/bmj.300.6718.170

Cited by 8 publications

(5 citation statements)

References 3 publications

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“…The GPASS system is widely used throughout Scotland, and one of its main uses is the administration of repeat prescriptions. 15 The 29 practices were sent an electronic questionnaire (EQ) computer disk, 15 which interrogated the practice GPASS database, and downloaded names and addresses of all patients recorded as being in receipt of regular prescriptions for an analgesic [all drugs listed in the British National Formulary 16 Section 4.7 (analgesics), Section 10.1.1 (non-steroidal anti-inflammatory drugs) and Section 10.3.2 (rubefacients and other topical antirheumatics) except legally controlled drugs such as morphine (prescriptions for which cannot be generated legally by computer in the UK)]. Previous work 17 had shown that only a very small proportion of patients who receive regular pain-related medication would be missed by not searching for controlled drugs, nor for aspirin, tricyclic anti-depressants or anti-convulsants, all of which are primarily prescribed regularly for non-painful conditions.…”

Section: Methodsmentioning

confidence: 99%

The 'number needed to sample' in primary care research. Comparison of two primary care sampling frames for chronic back pain

Smith

Hannaford²,

Elliott

et al. 2005

Family Practice

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The repeat prescription sampling method was approximately five times more efficient than the general population method. However demographic and clinical differences in the repeat prescription sample might hamper extrapolation of findings to the general population, particularly in an epidemiological study, and demonstrate that simple comparison with age and gender of the target population is insufficient.

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Section: Methodsmentioning

confidence: 99%

The 'number needed to sample' in primary care research. Comparison of two primary care sampling frames for chronic back pain

Smith

Hannaford²,

Elliott

et al. 2005

Family Practice

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“…For example, using two murine lymphoma cell lines nucleoids from irradiated radiosensitive LY5178S cells failed to be as effectively compacted by ethidium bromide as radioresistant LY5178R cells (Kapiszewska et al, 1989). Also, in a comparative study between inherently radiosensitive human ataxia telangiectasia (AT) fibroblasts and cells derived from normal individuals, the AT cells also demonstrated a larger nucleoid expansion after irradiation (Taylor et al, 1990). Finally, in studies with lymphocyte systems, using a centrifugation technique to quantify loop domain size, a correlation has been drawn between radiosensitivity and a larger domain size (Filipovich et al, 1982;Van Rensburgh et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

A correlation between nuclear supercoiling and the response of patients with bladder cancer to radiotherapy

Lynch

Anderson²,

Wallace³

et al. 1991

Br J Cancer

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Summary Single cell tumour suspensions were prepared from biopsy and urine samples from 28 patients with muscle invasive transitional cell carcinoma of the bladder. Nuclear extracts (nucleoids) containing intact chromatin were isolated from these cells and the condensation of DNA supercoils measured by the light scattered from individual nucleoids within a flow cytometer. Exposure of these nucleoids to 10 pgmlP' ethidium bromide produced 78.9% increase in light scatter compared to those treated with 501 gml-'. This finding is consistent with the known effect of ethidium bromide on DNA supercoiling and confirms that the light scatter signal is responding to changes at this level of DNA organisation. Cell samples were also exposed to 12 Gy of gamma radiation and the effect on nucleoid light scatter recorded. Of the patients studied prior to radiotherapy, those with persistent disease 3 months after treatment generated an increase in nucleoid light scatter of + 9.35 ± 4.8% after 12 Gy irradiation, of these, 2/14 produced nucleoids that relaxed by more than 10% compared to controls. Those patients with no evidence of disease after radiotherapy gave an increase in nucleoid light scatter after in vitro irradiation of + 19.3 ± 4.5% of which 10/14 (71%) relaxed by more than 10%. It is proposed that the increased relaxation within the supercoiled DNA from patients whose tumours were undetectable 3 months after therapy, is related to the inherent radiosensitivity of these tumour cells. Such a difference in nucleoid response within tumour cells from patients that responded to radiation may arise due to a decreased affinity of DNA loops for the nuclear matrix. This structural change, at a site associated with the initiation of DNA synthesis, may affect the ability of cells to continue successful cell division after radiation damage.

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“…In general practice during this decade, the use of computers and other technology has increased rapidly (Taylor et al,1994), and the vast majority of practices are now dependent upon technology to some degree to manage their business activities and clinical care effectively. The Project therefore took the stance that the workplace is not simply a social system, so that understanding behaviour at work depends on integration of social and technological factors.…”

Section: Sociotechnical Systems Frameworkmentioning

confidence: 99%

The practice characterization model: the importance of organizational life cycles and targeted interventions in general medical practice

Atkins

Duffy

Bain

2001

Health Planning & Management

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In response to a climate of constant change and increasing demand for services, general practice in the UK has undergone significant modification over the last 10 years. It has become a multi-disciplinary organisation encouraged by funding bodies to plan for service delivery using a more structured team based approach. In Tayside in 1996, practices were charged with producing formal Practice Development Plans (PDPs) which would focus on priority areas aligned with the Health Boards own strategic plan--those were teamwork, information management and technology, and clinical service delivery. The University of Dundee's Department of General Practice successfully applied for funding to develop ways of facilitating practices so that they could a) identify their own development priorities, and b) plan and implement action and learning to see these priorities through. Using action research methodology, the project attempted to create a climate for change, provide support and training to see the changes implemented, and ensure commitment to the changes from all members of the practice team. The Facilitator adopted a flexible style varying her role between expert, guide and support. Analysis of progress made by different practices, coupled with the Facilitator's in depth knowledge of them, suggested the importance of certain key aspects of practice organisation and culture. A practice characterisation model identified practices which were stable, currently coping, proactive and ready to face the challenge of change as best placed to engage in a full scale development programme. Other profiles suggested a range of alternative interventions as more likely to be acceptable and productive.

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General practice computing in Scotland.

Cited by 8 publications

References 3 publications

The 'number needed to sample' in primary care research. Comparison of two primary care sampling frames for chronic back pain

The 'number needed to sample' in primary care research. Comparison of two primary care sampling frames for chronic back pain

A correlation between nuclear supercoiling and the response of patients with bladder cancer to radiotherapy

The practice characterization model: the importance of organizational life cycles and targeted interventions in general medical practice

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