General Machine Learning Model, Review, and Experimental-Theoretic Study of Magnolol Activity in Enterotoxigenic Induced Oxidative Stress

Deng, Yanli; Liu, Yong; Tang, Shaoxun; Zhou, Changlin; Han, Xuefeng; Xiao, Wenjun; Pastur-Romay, Lucas Antón; Vázquez-Naya, José M.; Loureiro, Javier Pereira; Munteanu, Cristian R.; Tan, Zhiliang

doi:10.2174/1568026617666170821130315

Cited by 10 publications

(7 citation statements)

References 50 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perioperative hemodynamic changes generate more oxygen radicals, which can damage tissues after oxidation reactions with lipids in tissues, producing MDA [20]. SOD is a very important class of antioxidant enzymes in the body, which can scavenge oxygen radicals by catalytic reduction reactions [21]. In this study, SOD level decreased in both the observation group and the control group at the T2 time point compared with T1, and ROS and MDA levels increased compared with T1.…”

Section: Discussionmentioning

confidence: 54%

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Wang¹,

Xu²

2021

Journal of Healthcare Engineering

View full text Add to dashboard Cite

Objective. To analyze the effect of combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for laparoscopic cholecystectomy (LC) for patients with gallbladder lesions. Method. 93 patients with gallbladder lesions in our hospital were divided into 2 groups by the random number table method. 46 patients in the control group applied oxycodone hydrochloride injection in anesthesia, and 47 patients in the observation group applied oxycodone hydrochloride injection combined with dexmedetomidine in anesthesia. Result. The T1 and T2 MAP levels in the observation group were lower than those in the control group ( P < 0.05 ), and the difference between T3 and the control group was not significantly significant ( P > 0.05 ). The T1 to T3 HR level in the observation group were lower than those in the control group ( P < 0.05 ). The rate of excessive sedation (10.64%) and sedation inefficiency (12.77%) in the observation group was lower than that in the control group (28.26% and 30.43%), and the rate of satisfactory sedation (76.60%) was higher than that in the control group (41.30%) ( P < 0.05 ). The postoperative awakening, tracheal tube removal, and first anal venting time were shorter in the observation group than in the control group ( P < 0.05 ). The WHO scores of incisional pain at 6, 12, 24, and 48 hours after the operation were lower in the observation group than in the control group ( P < 0.05 ). The T2 SOD level in the observation group was higher than that in the control group, and the ROS and MDA levels were lower than those in the control group ( P < 0.05 ). The incidence of side effects of anesthetic in the observation group was 17.02%, which was not statistically different from the control group of 13.04% ( P > 0.05 ). Conclusion. The combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for LC for patients with gallbladder lesions can achieve better sedation and analgesia effect, accelerate postoperative awakening and recovery, and control oxidative stress and fluctuations in signs, without increasing anesthesia-related side effects.

show abstract

Section: Discussionmentioning

confidence: 54%

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Wang¹,

Xu²

2021

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…[18–20] At present, a large number of studies have confirmed that the changes in the levels of MDA and SOD reflect the ability of anti-lipid peroxidation and scavenging oxygen free radicals. [21,22] In this study, we found that edaravone could significantly inhibit the serum MDA content in patients with PQ poisoning, and increase the content of serum SOD. All of these revealed severe anti-lipid peroxidation damage and the ability to scavenge oxygen free radicals.…”

Section: Discussionmentioning

confidence: 63%

Retrospective study of clinical features and prognosis of edaravone in the treatment of paraquat poisoning

et al. 2019

View full text Add to dashboard Cite

To observe whether edaravone can protect organs and inhibit pulmonary fibrosis in patients with paraquat poisoning and to provide a method for clinical intervention for paraquat poisoning. Forty-four cases of paraquat poisoning were collected from March 2011 to December 2017 in our hospital. Eighteen cases from March 2011 to November 2013 did not receive edaravone treatment and were considered the control group, and 26 cases from January 2014 to December 2017 were treated with edaravone and were considered the observation group. Injuries to the central nervous system, heart, liver, kidney, and digestive system were evaluated on at 24 hours, 3 days, and 7 days after hospitalization. The expression of serum inflammatory factors (interleukin [IL]-6, IL-10, tumor necrosis factor-α [TNF-α]) and oxidative stress correlation (superoxide dismutase [SOD] and malondialdehyde [MDA]) were assayed at 24 hours, 3 days, and 7 days after being hospitalized. After 7, 14, and 30 days, the changes in pathological lung characteristics in the 2 groups were assessed, and survival rates were calculated. Edaravone significantly increased the serum levels of SOD and obviously markedly reduce the serum levels of IL-6, IL-10, TNF-α, and MDA in patients poisoned with paraquat ( P < .05). Edaravone significantly protected the liver ( P = .021), cardiovascular ( P = .031), and renal ( P = .028) organs of patients from paraquat poisoning-induced injury after 7 days but had no significant protection or improvement on respiratory and digestive tract damage. Edaravone delayed the occurrence of pulmonary fibrosis and increase the survival time of patients at 7 and 14 days ( P < .05). However, the 1-month follow-up found that edaravone did not reduce pulmonary fibrosis (77.8% vs 73.1%, P = .615) and did not increase the survival rate of the patients (61.1% vs 65.3%, P = .853). Edaravone is beneficial for protecting the kidneys and liver from paraquat poisoning through reducing oxidative stress and inhibiting inflammatory response. It can also inhibit the pulmonary fibrosis process and prolong the survival time of the patients. However, no significant improvements were seen in the probability of pulmonary fibrosis and the survival rate.

show abstract

“…IL-1β, IL-6, and IL-8 not only regulate the reorganization of cytoskeletal proteins, but also directly lead to the rearrangement of TJs proteins and thus reduce the barrier function. 44 Besides, evidences suggested that oxidative stress is closely related to intestinal barrier dysfunction, mainly due to the ability of oxidative stress to disrupt TJ proteins. Pretreatment with ICA and pICA significantly attenuated ETEC K88-induced pro-inflammatory cytokines expression in jejunum of piglets and IPEC-J2 cells.…”

Section: Discussionmentioning

confidence: 99%

“…Among these mechanisms, the accumulation of oxidative stress intermediates has received great attention. 44 Besides, evidences suggested that oxidative stress is closely related to intestinal barrier dysfunction, mainly due to the ability of oxidative stress to disrupt TJ proteins. 45,46 Our data clearly showed that ETEC K88 challenge expression of p38 in IPEC-J2 cells.…”

Section: Discussionmentioning

confidence: 99%

Icariin and its phosphorylated derivatives alleviate intestinal epithelial barrier disruption caused by enterotoxigenic Escherichia coli through modulate p38 MAPK in vivo and in vitro

Xiong

Huang

et al. 2019

The FASEB Journal

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractThe natural product icariin (ICA) and its phosphorylated derivatives (pICA) have been shown to have outstanding anti-inflammatory and antioxidant properties. This study was to explore the protective effects of ICA and pICA on the intestinal epithelium of enterotoxigenic Escherichia coli (ETEC)-induced piglet diarrhea and its underlying mechanisms in vivo and in vitro. ETEC K88 increased pro-inflammatory cytokine expression, activated oxidative stress and inhibited antioxidant enzyme activity, induced phosphorylated p38 MAPK gene and protein expression, disrupted intestinal barrier function, and led to diarrhea in piglets. Pretreatment with ICA and pICA effectively alleviated ETEC-induced intestinal barrier dysfunction in vivo and in vitro. Pretreatment with p38 MAPK inhibitor (SB203580) significantly rescued the IPEC-J2 cells barrier function damaged by ETEC challenge. However, pretreatment with p38 MAPK activator (anisomycin) did not alleviated the IPEC-J2 cells barrier function damaged by ETEC challenge. Our data demonstrated that ICA and pICA regulate the inflammatory response and oxidative stress of intestinal epithelial cells by inhibiting the expression of p38 MAPK, thereby alleviating ETEC K88-induced disruption of intestinal barrier function and intestinal permeability. These findings provide new insights into the prevention and treatment of intestinal barrier dysfunction induced by ETEC K88. K E Y W O R D S enterotoxigenic Escherichia coli K88, icariin, intestinal barrier function, p38 MAPK, phosphorylated icariin 1784 | XIONG et al.

show abstract

General Machine Learning Model, Review, and Experimental-Theoretic Study of Magnolol Activity in Enterotoxigenic Induced Oxidative Stress

Cited by 10 publications

References 50 publications

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Retrospective study of clinical features and prognosis of edaravone in the treatment of paraquat poisoning

Icariin and its phosphorylated derivatives alleviate intestinal epithelial barrier disruption caused by enterotoxigenic Escherichia coli through modulate p38 MAPK in vivo and in vitro

Contact Info

Product

Resources

About