General Lack of Correlations between Age and Signs of the Metabolic Syndrome in Subjects with Non-diabetic Fasting Glucose Values

Abstract

In the present investigation, a cross-sectional analysis was carried out over a wide age range of subjects. It is noteworthy that fasting glucose levels and the other major elements of metabolic syndrome did not change significantly with advancing age. These results demonstrate that decreasing insulin resistance and fasting glucose levels may be an important way to overcome the adverse effects and perturbations of advancing age-induced consequences of metabolic syndrome.

Circulating ALT Levels in Healthy Volunteers Over Life-Span: Assessing Aging Paradox and Nutritional Implications

“…Concentrating on the last point, it is important to note that circulating ALT is not the only paradoxical aging health factor, even though the majority of papers dealing with the ALT aging paradox generally ignore the presence of similar happenings with other health parameters (8-11). For example, FBG levels are particularly illuminating in this regard ( Figures 6 and 7, Table 1) (10). Further, in present and past datum sets, body weight and body fat decline markedly in a similar fashion in the elderly past age 65 years (Table 2) (10).…”

“…Therefore, the present close replication of results in the text, figures, and tables emanating from more than 10,000 subjects clearly refutes the "by chance" assumption. In further support, many others have also reported decreasing levels of circulating ALT in the very elderly (10,(12)(13)(14)(15). These additional papers generally refer to smaller number of subjects, do not concentrate on specific data for the younger age groups (21-64 years), actually do not reveal findings from individual years of age, and do not extensively examine the aging paradox for other elements of MS.…”

“…Thus, the liver could sustain less abuse and perhaps even shrink, with resultant lowering of ALT. In addition, less caloric consumption brings about enhanced insulin sensitivity and lower FBG (10,(31)(32)(33)(34). We have been well aware that type 2 diabetes is a form of premature aging with a shortened lifespan and that an adjustment to a better lifestyle could be beneficial (31,32,(35)(36)(37)(38).…”

“…In a recent cross-sectional investigation centering on relatively healthy, nondiabetic subjects, circulating ALT showed significantly decreasing levels with advancing age (65-84 years) after displaying a significant positive trend at a younger yearly range (21-64 years) (10). Unlike this paradox with circulating ALT, levels of AST even in the elderly appeared to gradually increase or at least level off and not CONTACT Harry G. Preuss preusshg@georgetown.edu decrease at the highest observed life-span (2,10). This agerelated conundrum in serum ALT measurements has been mentioned previously via many investigators who had included the most elderly in their studies (11)(12)(13)(14)(15).…”

“…Because of important implications behind the "ALT aging paradox," additional data were gathered from a much larger population of subjects for duplicative and replicative purposes. They further emphasized the strong linkage of hepatic fat accumulation with other elements of MS, especially the close association with IR, a perturbation commonly dietary induced (10,13,16). Suffice it to say, the new, expanded findings corroborate the earlier observations and add further knowledge concerning the basis for the age-related decline in circulating ALT levels (5,(10)(11)(12)(13)(14)(15).…”