General Introduction: Reminiscences and Reflections on Fifty Years of the Endocrine Pancreas

Abstract

The sections in this article are: Beginnings Endocrine Nature of the Pancreas Action Mechanisms Landmarks in Protein Phosphorylation: Mechanism of Action of Glucagon Insulin Early Development of Ideas About the Mechanism of Action of Insulin Insulin Secretion and Biosynthesis Fuels: Consumption and Selection—The Glucose Fatty Acid Cycle and the Role of the PDH Complex Fuel Consumption and Selection The Glucose Fatty Acid Cycle Role of the Pyruvate Dehydrogenase Complex Physiopathological Significance of Pyruvate Dehydrogenase Kinase Regulation in Humans The Thrifty Phenotype Hypothesis in Relation to Insulin Secretion, Insulin Insensitivity, and the Origins of Non‐Insulin‐Dependent Diabetes Mellitus Where Next?