General health status in psoriasis patients, as assessed by the 12‐item Short Form (SF‐12) Health Survey, is poorly associated with Psoriasis Area Severity Index

Sampogna, Francesca; Mastroeni, Simona; Pallotta, Sabatino; Gubinelli, Emanuela; Teofili, P; Fusari, Roberta; Uras, Claudia; Quinto, Rossella Mattea; Napolitano, Monica; Abeni, Damiano

doi:10.1111/jdv.15495

Cited by 6 publications

(4 citation statements)

References 9 publications

(11 reference statements)

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“…These results also support previous findings concerning other skin conditions, such as psoriasis ( 35 , 36 ), which indicate that there is not a linear correlation between clinical severity and the psychosocial impact of a disease. In fact, clinical severity measures are based mainly on clinical signs, which do not necessarily correspond with the burden that the disease places on the patient.…”

Section: Discussionsupporting

confidence: 91%

Correlation between Depression, Quality of Life and Clinical Severity in Patients with Hidradenitis Suppurativa

et al. 2020

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Depression is frequent in patients with hidradenitis suppurativa. However, its relationship with quality of life and clinical severity needs further investigation. In this cross-sectional study, 341 adult, consecutive patients with hidradenitis suppurativa completed the 12-item General Health Questionnaire (GHQ-12), which has been shown to be able to identify cases of major depressive disorder in dermatological patients. The frequency of depression in hidradenitis suppurativa patients was 29.0%. In patients with depression, severity (International Hidradenitis Suppurativa Severity Score System (IHS4)), quality of life (Skindex-17; Dermatology Life Quality Index (DLQI)), and health status (36-item Short Form Health Survey (SF-36)) were significantly worse compared with patients with no depression. The highest linear correlation was observed between GHQ-12 and the psychosocial scale of the Skindex-17 and the SF-36 mental scale. In contrast, correlation between GHQ-12 and clinical severity was poor. Depression is an important comorbidity in hidradenitis suppurativa, which is strongly associated with impairment in quality of life, but not linearly correlated with clinical severity.

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Section: Discussionsupporting

confidence: 91%

Correlation between Depression, Quality of Life and Clinical Severity in Patients with Hidradenitis Suppurativa

et al. 2020

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“…30,31 Also a previous study 32 reported that "the physical assessment of the severity of psoriatic lesions, as measured by the PASI or SAPASI, did not correlate with any of the three measures of quality of life." This finding was recently confirmed, 33 with results showing a total lack of correlation between SF-12 scores and PASI. Interestingly, on the basis of our data, the PGA 34 seems to perform better than the PASI, though such better performance is limited to the physical aspects of health, i.e., to the PCS score.…”

Section: Discussionsupporting

confidence: 59%

Use of the SF‐12 questionnaire to assess physical and mental health status in patients with psoriasis

Sampogna

Mastroeni

Pallotta

et al. 2019

The Journal of Dermatology

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Health‐related quality of life (HRQoL) in psoriasis patients is generally measured using disease‐ or dermatology‐specific questionnaires. Our objective was to use the generic 12‐item Short Form Health Survey (SF‐12) instrument to measure the physical and mental impact of psoriasis and to compare scores with those already published for different diseases. An observational study was conducted among mild‐to‐severe psoriasis outpatients. Health status was assessed by the SF‐12, which includes a physical (PCS) and a mental (MCS) scale. The 12‐item General Health Questionnaire (GHQ‐12) was used to assess the possible presence of depression or anxiety, and the Skindex‐17 to measure dermatology‐specific HRQoL. Statistical analyses were performed to estimate the association between physical and mental health status and demographic and clinical characteristics. The study population included 1592 patients. Psoriasis PCS scores were similar to the general population and to non‐severe diseases such as allergies, dermatitis, or back pain, while MCS mean scores were very similar to that of depression, and lower than those of all the other chronic conditions. Poor physical health was associated with female sex, older age, lower educational level, joint involvement, ≥2 comorbidities, moderate to very severe clinical status, GHQ‐12 score ≥4, and moderate to severe Skindex‐17 psychosocial scores. Poor mental health was associated with younger age (<30 years), GHQ ≥ 4, and severe Skindex‐17 psychosocial scores. In conclusion, a general health measure, such as the SF‐12, appears to be able to capture, in psoriasis patients, the burden of the disease both from a physical and a mental point of view.

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“…PASI and PGA) and patient-reported outcomes (PROs) is a crucial issue that we consistently reported over time. 21,22 It further underlines the fact that the 'disease', as evaluated by the dermatologists, has different implications from the 'illness' experienced by the patients. This different view of the skin condition may hamper, for example, the clinician-patient relationship and adherence to treatment, and may reduce patient satisfaction and trust in a given medical institution.…”

Section: Discussionmentioning

confidence: 99%

Sex‐ and gender‐associated clinical and psychosocial characteristics of patients with psoriasis

et al. 2020

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Background. Sex and gender may affect disease prevalence, adverse effects and response to therapy. Aim. To analyse sex and gender differences in outpatients with psoriasis. Methods. A cross-sectional study was conducted at IDI-IRCCS, Rome, over a 3-year period. In total, 3023 patients with psoriasis were enrolled. Anthropometric and demographic characteristics were recorded, and a dermatologist evaluated the clinical severity of disease. Quality of life (QoL) questionnaires were collected. Univariate and multivariate analyses were performed to examine factors associated with sex. Results. We found sex-and gender-associated differences in clinical characteristics, disease severity, psychological distress and quality of life. Male sex was associated with body mass index, smoking, alcohol consumption, Psoriasis Area Severity Index ≥ 10 and age at onset ≥ 20 years. Female sex was associated with family history of diabetes, joint involvement, clinical type other than diffuse plaque psoriasis, higher psychological distress and a greater effect on QoL. Conclusion.Our study identified sex and gender differences of potential clinical relevance in psoriasis.

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General health status in psoriasis patients, as assessed by the 12‐item Short Form (SF‐12) Health Survey, is poorly associated with Psoriasis Area Severity Index

Cited by 6 publications

References 9 publications

Correlation between Depression, Quality of Life and Clinical Severity in Patients with Hidradenitis Suppurativa

Correlation between Depression, Quality of Life and Clinical Severity in Patients with Hidradenitis Suppurativa

Use of the SF‐12 questionnaire to assess physical and mental health status in patients with psoriasis

Sex‐ and gender‐associated clinical and psychosocial characteristics of patients with psoriasis

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