General genetic aspects of psoriasis and type 2 diabetes mellitus

Svechnikova, E.V. Svechnikova; Спицына, А В; Немчанинова, О. Б.; Лыкова, С. Г.; Maksimova, Yu.V.; Maksimov, V. N.

doi:10.21145/2499-9954-2018-3-124-127

2018

DOI: 10.21145/2499-9954-2018-3-124-127

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General genetic aspects of psoriasis and type 2 diabetes mellitus

E.V. Svechnikova Svechnikova¹,

А В Спицына²,

О. Б. Немчанинова³

et al.

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Cited by 4 publications

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“…It has been shown that their carriers are more likely to suffer from liver diseases [16] and have an increased risk of tuberculosis [15,17]. Allele -174G is considered a risk factor for squamous cell lung cancer and chronic obstructive pulmonary disease [18], cancer and fundic atrophy of the stomach [19], ovarian cancer [20], intrauterine infection of the fetus [21], development of cerebral arteriovenous malformation [22] and is associated with the risk of developing type 2 diabetes [23,24]. Allele -572С has also been associated with ischemic stroke in indigenous West African men [25].…”

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confidence: 99%

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

et al. 2023

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—The study of immune response and inflammation gene polymorphisms in a genogeographic context is relevant in the study of human populations. Here, in the indigenous populations of Siberia the frequencies of polymorphic variants ‒ 174G/C (rs1800795) and ‒572C/G (rs1800796) of the IL6 gene encoding the proinflammatory cytokine IL-6 were determined. For the first time, it was shown that the frequencies of the ‒174G and ‒572C alleles, which determine increased inflammatory response and are also associated with several diseases were statistically significantly higher in ethnic groups of Buryats, Teleuts, Yakuts, Dolgans and Tuvinians than in Russians living in Siberia. These values were in the intermediate position between those in the European and East-Asian groups. We hypothesize an adaptive role of these IL6 genetic variants in human settlement from Africa to the Eurasian continent. However, due to the departure from the traditional way of life and the increasing anthropogenic environmental pollution, the risk of diseases whose pathogenesis is based on inflammation in indigenous Siberian populations is likely increased.

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confidence: 99%

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

et al. 2023

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Cutaneous manifestations of endocrine disorders

Gazdanova,

Gorodetskaya,

Perkov

et al. 2022

Klin. dermatol. venerol.

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Characteristics of Peripheral Nervous System in Patients With Psoriasis

Машина

Нестеров

Korobochkina

et al. 2021

Ulyanovsk Medico-Biological Journal

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Psoriasis is a chronic non-infectious inflammatory dermatosis characterized by excessive proliferation of epithelial cells, impaired differentiation, often involving the musculoskeletal system. Materials and Methods. The authors examined 60 patients with psoriasis, 39 men and 21 women, aged from 21 to 69 (the average subject age was 46.3±13.94). All patients underwent a standard dermatological and neurological examination. Motor function was assessed according to knee jerk, elbow jerk and Achilles jerk. Pain sensitivity was established after pricking the thumb dorsum with a special blunt-end needle. Nonparametric methods were used for statistical analysis. The Mann-Whitney U-test was used to check the differences between independent groups of patients. The distribution of characteristic was assessed using a probability calculator. Differences were statistically significant at 95 % probability (p<0.05). Results. Mild psoriasis was found in 8 patients (13.3 %), moderate-to-severe psoriasis – in 14 patients (23 %) (PASI=11–30), severe psoriasis – in 38 patients (63.7 %) (PASI>30). Type I psoriasis was detected in 32 patients (53.2 %), type II – in 28 patients (46.8 %). Dysfunctions of the peripheral nervous system were found in 30 patients (50 %). In 12 subjects (20 %) symmetrical sensory and motor disturbances were observed in the distal parts of all four limbs. In 9 patients (15 %) symmetrical decrease in knee and Achilles jerks was observed. Symmetrical decrease in tactile and temperature sensitivity in the distal parts of the lower extremities was noted in 9 patients with psoriasis (15 %). Conclusion. Distal symmetric sensorimotor polyneuropathy is common in patients with psoriasis. Severe psoriasis is accompanied by distal symmetric sensorimotor polyneuropathy. Key words: psoriasis, comorbidity, demyelination, polyneuropathy. Псориаз – это хронический неинфекционный воспалительный дерматоз, характеризующийся избыточной пролиферацией эпителиоцитов, нарушением их дифференциации, нередко вовлекающий в процесс опорно-двигательный аппарат. Материалы и методы. Обследовано 60 больных псориазом, из них 39 мужчин и 21 женщина в возрасте от 21 до 69 лет (средний возраст обследуемых 46,3±13,94 года). Всем больным проводился стандартный дерматологический и неврологический осмотр. Двигательная функция исследовалась с помощью оценки коленного, локтевого и ахиллова рефлексов. Болевая чувствительность устанавливалась после укола тыльной поверхности большого пальца специальной иглой с притупленным концом. Для статистического анализа использовались непараметрические методы. Для проверки отличий между независимыми группами больных применялся Mann – Whitney U-test. Распределение признака оценивалось с помощью вероятностного калькулятора. Статистические значимыми считались отличия при уровне вероятности более 95 % (p<0,05). Результаты. Легкая степень псориаза установлена у 8 (13,3 %) больных, умеренно тяжелый псориаз – у 14 (23 %) пациентов (индекс PASI 11–30 баллов), тяжелая форма псориаза – у 38 (63,7 %) больных (индекс PASI более 30 баллов). Псориаз I типа определялся у 32 (53,2 %) больных, II типа – у 28 (46,8 %). У 30 (50 %) больных обнаружены нарушения функции периферической нервной системы. У 12 (20 %) чел. наблюдались симметричные сенсорные и двигательные нарушения в дистальных отделах всех четырех конечностей. У 9 (15 %) чел. отмечалось симметричное снижение коленного и ахиллова рефлексов. Девять (15 %) больных псориазом имели симметричное снижение тактильной и температурной чувствительности в дистальных отделах нижних конечностей. Выводы. У больных псориазом часто встречается дистальная симметричная сенсорно-моторная полинейропатия. Тяжелое течение псориаза сопровождается дистальной симметричной сенсорно-моторной полинейропатией. Ключевые слова: псориаз, коморбидность, демиелинизация, полинейропатия.

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General genetic aspects of psoriasis and type 2 diabetes mellitus

Cited by 4 publications

References 0 publications

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

Cutaneous manifestations of endocrine disorders

Characteristics of Peripheral Nervous System in Patients With Psoriasis

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