General Characteristics of the O-glycosidic Bond

Body Distribution of Galactose-Containing Synthetic Polymer and Galactosylated Albumin

“…The formation of 1,2-cis-glycoside in such reaction is reported to be kinetically unfavorable. 10 The coupling constant between H-1 and H-2 in the NMR spectrum was 7.6 Hz, being consistent with that reported for J1-o-galactoside in D 2 0 (7.5 Hz), while that of ix-o-galactoside was 3.2 Hz. Thus, the Panomer is thought to be formed.…”

New Synthetic Glucosyl-Curcuminoids, and their 1H and 13C NMR Characterization, from Curcuma longa L.

“…The glycosidic linkage is usually obtained by reaction of an activated glycon anomeric centre with the hydroxyl function of a protected aglycon derivative [12]. Many different glycosilation processes have been explored, among which the Mitsunobu reaction [13], and the coupling reaction promoted by insoluble silver salts [14].…”

Methodology Development and Physical Organic Chemistry: A Powerful Combination for the Advancement of Glycochemistry

“…As complete newcomers to the glycosylation field, we were struck by the strong reliance of most practitioners of the art, 12 as continues to be the case today, 8a,8f on variations on the classical approach that derives its origins in the venerable Koenigs-Knorr and Helferich reactions of a century or more ago. We were equally struck by the less than perfect anomeric selectivities observed in the majority of cases and by the bewildering diversity of conditions reported in the literature.…”