General characteristics, features of cultivation and antibiotic resistance representatives of mycobacterium fortuitum group representatives (review of literature)

Abstract

Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M. fortuitum group, as the main pathogens among the group of fast-growing mycobacteria. The data on the modern classification based on the use of molecular genetic studies are indicated. The M. fortuitum group includes: Mycobacterium fortuitum, M. peregrinum, M. senegalense, M. porcinum, M. houstonense, M. neworleansense, M. boenickei, M. conceptionense, M. septicum, M. alvei. According to the new data, mycobacteria were divided into 5 clades (Abscessus-Chelonae, Fortuitum-Vaccae, Terrae, Triviale, Tuberculosis-Simiae), and based on molecular genetic studies, new genera in the Mycobacteriaceae family were isolated: Mycolicibacter spp., Mycolicibacillus spp., Mycolicibacillus spp., Mycobacteroides spp., Mycolicibacterium spp. In accordance with the new classification, representatives of the Mycobacterium fortuitum group belong to the genus Mycolicibacterium. The main epidemiological features of the main sources of the spread of mycobacteria, factors and ways of their transmission are indicated. Due to their wide distribution in the environment, representatives of the M. fortuitum group are capable of causing diseases of the pulmonary and extrapulmonary localization. The distinctive features of pathogenicity factors, due to which the course of the disease is determined, are noted. The article also indicates the main difficulties and features of determining the sensitivity to antimicrobial chemotherapy drugs, provides data on the main features of antibiotic resistance of M.fortuitum group. In preparing the review, literature sources obtained from international and domestic databases were used: Scopus, Web of Science, Springer, RSCI.

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

“…The presence of M. koreensis was also relevant to the poor overall survival of IPMN‐IC. The pathogenicity of M. koreensis and genus Mycolicibacillus has rarely been studied 30 . Mycobacterium , which is the traditional genus belonging to the same family as Mycolicibacillus , has been implicated as contributing to the etiology of cancer and impairing the function of immune cells 31 .…”

“…The pathogenicity of M. koreensis and genus Mycolicibacillus has rarely been studied. 30 Mycobacterium, which is the traditional genus belonging to the same family as Mycolicibacillus, has been implicated as contributing to the etiology of cancer and impairing the function of immune cells. 31 The roles of S. aureus and M. koreensis in the prognosis of IPMN-ICs need further exploration.…”

Central nervous system infection caused by Mycobacterium houstonense: A case report

“…Members of the M. fortuitum group can cause disease in fish and other animals including humans. This group includes M. fortuitum, Mycobacteria peregrinum , and the unnamed third biovariant complex ( Mycobacteria senegalense, Mycobacteria porcinum, Mycobacteria houstonense, Mycobacteria neworleansense, Mycobacteria boenickei, Mycobacteria conceptionense, Mycobacteria septicum , and Mycobacteria alvei ) ( 3 , 4 ). Here, we report a case of central nervous system (CNS) infection in China.…”

A clinical case and a review of Mycobacterium fortuitum infections direct diagnosis approach and treatment in a patient with leg fractures

“…With the improvement in the laboratory and diagnostic equipment for the characterization of microorganisms [6], we rapidly identified M. fortuitum by matrix-assisted laser desorption/ionization time-offlight mass spectrometry (MALDI-TOF MS) [7,8], 16S rRNA gene sequencing, and metagenomic nextgeneration sequencing (mNGS). We present a rare case study of a patient with M. fortuitum infection in a car accident amputee, including its diagnosis and treatment.…”