General Characteristics and Prognostic Factors of Pneumonia Cases DevelopedDuringPandemic(H1N1)Influenza-AVirus InfectioninTurkey

Özlü, Tevfik; Bülbül, Yılmaz; Tasbakan, Sezai; Kılıç, Hatice; Kuyucu, Tülin; Yıldız, Tekin; Özdemir, Tarkan; Duru, Serap; Öztuna, Funda; Adıgüzel, Nalan; Sağlam, Leyla; Coşkun, Ayşın Şakar; Örnek, Tacettin; Gündüz, Gazi; Filiz, Ayten; Özdemır, Levent; Okumuş, Gülfer

doi:10.5152/balkanmedj.2012.089

Cited by 7 publications

(9 citation statements)

References 16 publications

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“…Therefore, early estimation of the diagnosis and prompt treatment are lifesaving. Appropriate clinical evaluation, effective antiviral and antibacterial treatment, and monitoring the pneumonia's severity are critical for survival (1,(21)(22)(23). For these reasons, while we were monitoring CAP patients with H 1 N 1 infections, it was important to evaluate the severity of pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of 75 pandemic H1N1 influenza patientsfrom Turkey; risk factors for fatality

Kılıç¹,

Kanbay²,

Karalezli³

et al. 2015

Turk J Med Sci

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Background/aim: The 2009 influenza A (H 1 N 1 ) pandemic caused mild to severe illnesses and led to death in some cases. In this study, we aimed to evaluate the relationship between the serum D-dimer levels, CURB-65 scores, and the severity of pneumonia among patients with H 1 N 1 infections.Materials and methods: Sixty-eight patients who had probable H 1 N 1 infections were evaluated by clinical, radiological, and laboratory methods. The H 1 N 1 strain was specified by reverse transcription-polymerase chain reaction. Of 55 patients diagnosed with pneumonia, 18 exhibited H 1 N 1 positivity and 37 patients did not.Results: CURB-65 scores of pneumonia patients with H 1 N 1 (group 1) were higher than those of patients without H 1 N 1 (group 2) (P = 0.02). The D-dimer levels of group 1 were higher than those of group 2 (P = 0.001). Moreover, there was a positive correlation between D-dimer levels and CURB-65 scores in patients with H 1 N 1 -associated pneumonia (P = 0.001; r = 0.89). Conclusion:Increased D-dimer levels were observed in pneumonia patients with H 1 N 1 infection, which predicted the severity of pneumonia.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of 75 pandemic H1N1 influenza patientsfrom Turkey; risk factors for fatality

Kılıç¹,

Kanbay²,

Karalezli³

et al. 2015

Turk J Med Sci

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“…The study of Reyes et al showed lower leukocytes values in H1N1 positive cases than in bacterial pneumonia [9]. In the study conducted by Şahbudak Bal et al, a significant difference was obtained in the platelet values between H1N1 positive and negative patients [10].In the study of Özlü et al, a statistically significant difference was also determined in the platelet values from the laboratory findings between H1N1 positive and negative cases [11].Gürgün et al determined thrombocytopenia in influenza A (H1N1) cases significantly more frequently when compared to community-acquired pneumonia [12].In our study, upon comparing the laboratory values between influenza positive and negative patients, platelet counts were determined to be significantly lower in influenza-positive patients. In our study, it was also statistically determined that the elevation in the white blood cell, neutrophil, creatinine, AST and ALT counts, comorbidity status, and infiltration in the chest radiography have an active role in the admission rate of patients to the intensive care unit.…”

Section: Discussionmentioning

confidence: 98%

“…Mortality was found to also be high in patients with comorbidity. In the study of Özlü et al, significant results were obtained between H1N1 positivity, neutrophil, platelet, and BUN values and mortality in patients with pneumonia [11]. The result of these factors is that influenza has a wide range from a mild form of a spontaneously regressing disease to a severe disease table causing pandemics and increased mortality.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Patients with Suspected Influenza in the 2016 Winter Season

Yalçın¹

2017

Ann Clin Anal Med

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Özİnfluenza virüslerinin neden olduğu grip, hafif seyirli spontan gerileyen hastalık tablosundan, ölümcül pandemilerle seyreden ağır hastalık tablosu gibi geniş bir yelpazeye sahiptir. Çalışmamızda 2016 yılı kış sezonunda Sivas Numune Hastanesi'ne grip şüphesi ile başvuran ve nazofarengeal sürüntü örnekleri alınan hastaların klinik ve laboratuvar özelliklerini analiz etmeyi amaçladık.Çalışmaya dahil edilen 34 hastanın 19'u erkek, 15'i kadındı. Yaş ortalaması 43.9±16.5 (en düşük17-en yüksek74) 'du. Hastaların 20'sinde (%57.1) komorbid hastalık mevcuttu. Hastaların 20'sinin (%57.1) akciğer grafisinde infiltrasyon vardı. Hastaların beyaz küre değerleri ortalama 9.645±7.446 (103 µL ), C-reaktif protein değerleri ortalama 4.6±4.7(mg/dL), kreatin kinaz değerleri ortalama 579±1.725(µL) idi. Nazofarengeal sürüntü sonuçlarında dokuz (%26.4) hastada H1N1, yedi (%20.5) hastada H3N2, üç (%8.8) hastada Influenza B tespit edildi. Sekiz hasta ex oldu. Komorbiditesi olan hastalarda mortalite yüksek bulundu (n=8, p = 0.008). Hastaların yoğun bakım ünitesine yatışında beyaz küre (p = 0.003), nötrofil (p = 0.002), kreatinin (p = 0.02), AST (p = 0.001), ALT (p = 0.04) değerlerinde anormallik, komorbidite durumu (p = 0.02) ve akciğer grafisinde infiltrasyon olmasının (p = 0.02) etkin rolü olduğu istatistiksel olarak saptandı. Sonuç olarak, genel durumu kötü, laboratuvar parametreleri bozuk, akciğer grafisinde infiltrasyonu olan hastaların yoğun bakım ünitesinde yakın takibi ve multidisipliner hekim yaklaşımı uygundur.Influenza, komorbid hastalıkların varlığında daha ağır seyretmektedir. Bu nedenle mevsimsel grip aşısı komorbiditesi olan kişilerde büyük öneme sahiptir. AbstractInfluenza, caused by influenza viruses, has a wide range from a mild form of spontaneously regressing disease table to a severe disease table showing a fatal pandemic course. In this study, we aimed to analyse the clinical and laboratory characteristics of patients who applied to Sivas Numune Hospital in the winter season of 2016 with the influenza-suspect and for whom nasopharyngeal swab samples were taken. Nineteen of the 34 patients included in the study were male and 15 were female. The average age was 43.9±16.5 (min17-max74) years. Comorbid disease was present in 20 (57.1%) of the patients. There was infiltration in the chest radiography of 20 (57.1%) of the patients. The average white blood cell counts of the patients were 9.645±7.446 (103 µL), the average C-reactive protein was 4.6±4.7 (mg/dL), and the average creatine kinase was 579±1.725 (µL). In the nasopharyngeal swab results, H1N1 was determined in nine (26.4%) patients, H3N2 in seven (20.5%) patients, and influenza B in three (8.8%) patients. Eight patients died. Mortality was found to be high in patients with comorbidity (n=8, p = 0.008). It was statistically determined that anomaly in white blood cell count (p = 0.003), neutrophil (p = 0.002), creatinine (p = 0.02), AST (p = 0.001) and ALT (p = 0.04) counts, comorbidity status (p = 0.02) and infiltration in the chest radiography (p = 0.02) had an ...

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“…SARI vakalarının %40'ının, solunum yolu viruslarının izole edildiği gruplarda ise hastaların %30'unun yoğun bakım ünitesinde takibinin gerektiği rapor edilmiştir (8). Ül-kemizde pandemi döneminde yapılan çok merkezli bir ça-lışmada ortalama yatış süresi 12.0±9.4 gün ve yoğun bakım ünitesinde takip gerekliliği %32.6 olarak bildirilmiştir (18). Snacken ve arkadaşları (19) tarafından influenza A (H1N1) virusunun baskın olduğu 2010-2011 sezonu verilerinin değer-lendirildiği çalışmada yatarak takip edilen hastaların %37'sinde yoğun bakım ünitesinde izlem gerekmiştir (19).…”

Section: İrdelemeunclassified

“…Pandemik influenza döneminde pnömoni nedeniyle yatarak takip edilen hastalarda yaş, altta yatan hastalık ve akciğer grafisinde infiltrasyon varlığı açısından mortalite ve şifay-la seyreden hasta grupları karşılaştırıldığında, gruplar arasın-da fark saptanmamış (sırasıyla p=0.238; p=0.575; p=0.310); aynı çalışmada yoğun bakım ünitesine yatış gerekliliği mortaliteyle seyreden grupta daha fazla (p<0.001) bulunmuştur (18). PCR pozitifliği olan SARI vakalarında da yoğun bakım ünitesine yatışın mortalite riskini artırdığı rapor edilmektedir (17).…”

Section: İrdelemeunclassified

Evaluation of Patients Diagnosed With Severe Acute Respiratory Tract Infection: 2015-2016 Influenza Season

et al. 2017

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Objective: This study aimed to determine the demographical and clinical characteristics of patients followed with severe acute respiratory illness (SARI) during 2015-2016 influenza season. Methods: Patients followed with a diagnosis of SARI between 15 December, 2015 and 22 May, 2016 were included in the study. The patients were evaluated for demographic and clinical characteristics. Respiratory tract multiplex polymerase chain reaction (PCR) test was performed for all patients' nasopharyngeal smear samples. Results: A total of 107 patients were included in the study. Of the patients, 69 (64.5%) were male, and median age was 68 (range, 0-95) years. Mean duration of complaints before admission was 3.8 days. Mean hospitalization time was 11.7 days, and 23.4% of patients were followed in intensive care unit. Most frequent admissions were between second and seventh weeks of 2016. Viral agents were found in 41(38.3%) patients in respiratory tract multiplex polymerase chain reaction (PCR) test. Of the agents, 80.5% were influenza A virus (63.4% H1N1, 7.3% H3N2, 9.7% influenza A), 14.6% were influenza B virus, 2.4% were coronavirus OC43, and 2.4% were human metapneumovirus. Crude mortality was 15.9%, SARI-specific mortality was 8.4%, influenza A (H1N1)-related mortality was 11.5%. There were no significant differences for underlying diseases and laboratory findings other than presence of chronic obstructive pulmonary disease, and elevated alanine and aspartate aminotransferase levels. Admission to intensive care unit and mortality were similar for both groups. When patients were evaluated according to the duration of complaints prior to admission, PCR positivity, necessity for intensive care unit admission and mortality were not found to be significantly different between patients with ≤4 Özet Amaç: Bu çalışmada 2015-2016 influenza sezonunda hastanemizde ağır akut solunum yolu hastalığı (SARI) tanısıyla takip edilen hastaların demografik ve klinik özelliklerinin ve bölge-mizde baskın virus suşlarının belirlenmesi amaçlandı. Yöntemler: Hastanemizde 15 Aralık 2015-22 Mayıs 2016 tarihleri arasında SARI tanısıyla izlenen hastalar çalışmaya dahil edildi. Hastaların demografik ve klinik özellikleri değerlendirmeye alındı. Tüm hastaların nazofaringeal sürüntü örnekleri, solunum yolu multipleks polimeraz zincir reaksiyonu (PCR) testiyle incelendi. Bulgular: Çalışmaya 107 hasta dahil edildi. Hastaların 69 (%64.5)'u erkek, ortanca yaş 68 (20-95 arasında) idi. Başvuru ön-cesi şikayet süresi ortalama 3.8 gün olarak bulundu. Ortalama yatış süresi 11.7 gün olan hasta grubumuzda, hastaların %23.4'ü yoğun bakım ünitesinde takip edildi. En sık başvuru 2016 yılının ikinci ve yedinci haftaları arasında oldu. Solunum yolu multipleks polimeraz zincir reaksiyonu (PCR) testinde 41 (%38.3) hastada viral etken saptandı. Etkenlerin %80.5'i influenza A virusu (%63.4 H1N1, %7.3 H3N2, %9.7 influenza A), %14.6'sı influenza B virusu, %2.4'ü koronavirus OC43 ve %2.4'ü insan metapnömovirus idi. Kaba mortalite %15.9, SARI'ye bağlı mortalite %8.4...

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General Characteristics and Prognostic Factors of Pneumonia Cases DevelopedDuringPandemic(H1N1)Influenza-AVirus InfectioninTurkey

Cited by 7 publications

References 16 publications

Clinical characteristics of 75 pandemic H1N1 influenza patientsfrom Turkey; risk factors for fatality

Clinical characteristics of 75 pandemic H1N1 influenza patientsfrom Turkey; risk factors for fatality

Evaluation of Patients with Suspected Influenza in the 2016 Winter Season

Evaluation of Patients Diagnosed With Severe Acute Respiratory Tract Infection: 2015-2016 Influenza Season

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