GENERAL CARDIOLOGY: Thyroid disease and the heart

Toft, A. D.; Boon, Nicholas A.

doi:10.1136/heart.84.4.455

Cited by 107 publications

(89 citation statements)

References 17 publications

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“…Although there is an increased systemic vascular resistance, overall there is a decrease in systemic blood volume and consequently a reduction in GFR. 4 It has also been suggested that the increase in circulating creatinine in hypothyroidism may be owing to increased creatinine release from muscle tissue as a result of myopathy and mild rhabdomyolysis. 6 However, other work has shown that there is no relationship between increased serum creatinine concentrations in hypothyroidism and serum creatine kinase activity.…”

Section: Discussionmentioning

confidence: 99%

“…3 Thyroid hormones have an effect on many organs including the heart, vasculature and the kidneys altering cardiac output, blood circulation and organ perfusion. 4 We wanted to assess the relationship between thyroid dysfunction and eGFR.…”

Section: Introductionmentioning

confidence: 99%

“…All of these result in an increase in the total blood volume resulting in an increased blood flow leading to an increased GFR. 4 An alternative explanation for the altered serum creatinine concentrations in thyroid disease is altered renal tubular secretion of creatinine. However, a previous study has shown that there was no difference in creatinine metabolism between hypothyroid and hyperthyroid patients.…”

mentioning

confidence: 99%

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The relationship between estimated glomerular filtration rate and thyroid function: an observational study

2008

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Background: Estimated glomerular filtration rate (eGFR) is now routinely reported by most National Health Service laboratories. There are many limitations when interpreting eGFR: thyroid dysfunction is not widely recognized as being one of these. Methods: We extracted from the pathology computer system results of all patients with hypothyroidism and hyperthyroidism who also had serum creatinine measured. We also extracted creatinine data on euthyroid patients. eGFR was calculated using the simplified Modification of Diet in Renal Disease Study equation. Results: The median eGFRs of the hypothyroid, euthyroid and hyperthyroid patients were 64, 77 and 107 mL/min/1.73 m 2 , respectively; all groups were significantly different from each other (P , 0.001). Conclusion: Thyroid dysfunction is associated with significant alterations in eGFR and actual GFR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The relationship between estimated glomerular filtration rate and thyroid function: an observational study

2008

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“…Thyroid diseases are comorbidities that can be associated with the HF syndrome 315 . More than 80% of the biologically active hormone triiodothyronine (T 3 ) is derived from the peripheral conversion of the prohormone thyroxine (T 4 ), which is secreted by the thyroid gland.…”

Section: Low T 3 Syndromementioning

confidence: 99%

I Diretriz Latino-Americana para avaliação e conduta na insuficiência cardíaca descompensada

Bocchi¹,

Vilas-Boas²,

Perrone³

et al. 2005

Arq. Bras. Cardiol.

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“…Hyperthyroidism increases heart rate and cardiac output and may aggravate heart failure, and hypothyroidism decreases heart rate and cardiac output and causes hypertension and hypercholesterolemia (17,18). In addition, elevated triiodothyronine (T 3 ) levels are associated with a threefold increased risk of coronary events (19), and cardiovascular mortality is substantially increased in individuals with subclinical hyperthyroidism (20) and in patients previously treated with radioiodine (21).…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormone increases mannan-binding lectin levels

Riis¹,

Hansen²,

Thiel³

et al. 2005

eur j endocrinol

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Background: Recent studies have indicated the existence of causal links between the endocrine and immune systems and cardiovascular disease. Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields. Methods: To test whether thyroid hormone regulates MBL levels, we studied eight patients with Graves' hyperthyroidism before and after methimazole therapy, eight healthy subjects before and after short-term experimental hyperthyroidism, and eight hypothyroid patients with chronic autoimmune thyroiditis before and after L-thyroxine substitution. Results: In all hyperthyroid patients, MBL levels were increased -median (range), 1886 ng/ml (1478 -7344) -before treatment and decreased to 954 ng/ml (312 -3222) after treatment (P ¼ 0.01, paired comparison: Wilcoxon's signed ranks test). The healthy subjects had MBL levels of 1081 ng/ml (312 -1578). Administration of thyroid hormones to these persons induced mild hyperthyroidism and increased MBL levels significantly to 1714 ng/ml (356-2488) (P ¼ 0.01). Two of the eight hypothyroid patients had undetectably low levels of MBL both before and after L-thyroxine substitution. The other six hypothyroid patients had decreased levels of MBL of 145 ng/ml (20-457) compared with 979 ng/ml (214 -1533) after L-thyroxine substitution (P ¼ 0.03, paired comparison: Wilcoxon's signed ranks test). Conclusion: Our data show that thyroid hormone increases levels of MBL. MBL is part of the inflammatory complement system, and this modulation of complement activation may play a role in the pathogenesis of a number of key components of thyroid diseases.

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GENERAL CARDIOLOGY: Thyroid disease and the heart

Cited by 107 publications

References 17 publications

The relationship between estimated glomerular filtration rate and thyroid function: an observational study

The relationship between estimated glomerular filtration rate and thyroid function: an observational study

I Diretriz Latino-Americana para avaliação e conduta na insuficiência cardíaca descompensada

Thyroid hormone increases mannan-binding lectin levels

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