General Aspects of Traumatic Neural Diseases and Requirements of Central Nervous System Implantable Biomaterials as Diagnostic and Therapeutic Tools

Domínguez‐Bajo, Ana; González‐Mayorga, Ankor; López-Dolado, Elisa; Serrano, Maria

doi:10.1007/978-3-030-81400-7_1

Cited by 1 publication

(2 citation statements)

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“…The brain is an intricate part of the CNS, responsible for integrating and regulating information in the nervous system along with the spinal cord. Injuries to the CNS due to diseases, disorders, or accidents are very critical as it hardly regenerates 46 . The rapid movement of astrocytes towards injured sites prevents further damage to the neural network by forming glial scars around the injured sites.…”

Section: Biomaterials For Brain Repairmentioning

confidence: 99%

“…Injuries to the CNS due to diseases, disorders, or accidents are very critical as it hardly regenerates. 46 The rapid movement of astrocytes towards injured sites prevents further damage to the neural network by forming glial scars around the injured sites. The brain damage became irreversible due to inadequate regeneration of neurons and axons and the development of glial scars at the lesion.…”

Section: Biomaterials For Brain Repairmentioning

confidence: 99%

See 1 more Smart Citation

Potential injectable hydrogels as biomaterials for central nervous system injury: A narrative review

Sarma,

Deka,

Rajak

et al. 2023

Ibrain

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Numerous modalities exist through which the central nervous system (CNS) may sustain injury or impairment, encompassing traumatic incidents, stroke occurrences, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Presently available pharmacological and therapeutic interventions are incapable of restoring or regenerating damaged CNS tissue, leading to substantial unmet clinical needs among patients with CNS ailments or injuries. To address and facilitate the recovery of the impaired CNS, cell‐based repair strategies encompass multiple mechanisms, such as neuronal replacement, therapeutic factor secretion, and the promotion of host brain plasticity. Despite the progression of cell‐based CNS reparation as a therapeutic strategy throughout the years, substantial barriers have impeded its widespread implementation in clinical settings. The integration of cell technologies with advancements in regenerative medicine utilizing biomaterials and tissue engineering has recently facilitated the surmounting of several of these impediments. This comprehensive review presents an overview of distinct CNS conditions necessitating cell reparation, in addition to exploring potential biomaterial methodologies that enhance the efficacy of treating brain injuries.

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Section: Biomaterials For Brain Repairmentioning

confidence: 99%

Section: Biomaterials For Brain Repairmentioning

confidence: 99%