2008
DOI: 10.1080/07420520802551386
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General Anesthetics Effects on Circadian Temporal Structure: An Update

Abstract: Disruptions of circadian and biological rhythms as well as general anesthesia can induce sleep disorders, resulting in an increase in sleepiness and drowsiness and a decrease in vigilance. It has been previously shown that circadian time can influence the pharmacologic sensitivity and the duration of action of general anesthetics. Studies on interactions between general anesthesia and circadian rhythms are few, but all of them suggest an important role of general anesthetics on circadian rhythms. General anest… Show more

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Cited by 58 publications
(32 citation statements)
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“…A growing body of evidence supports a strong association between surgery under general anesthesia and disturbances in circadian rhythms, which is likely to result in sleep problems and cognitive dysfunctions after surgery [17,18]. Specific medications used during general anesthesia are thought to play a role in these circadian disruptions.…”
Section: Discussionmentioning
confidence: 99%
“…A growing body of evidence supports a strong association between surgery under general anesthesia and disturbances in circadian rhythms, which is likely to result in sleep problems and cognitive dysfunctions after surgery [17,18]. Specific medications used during general anesthesia are thought to play a role in these circadian disruptions.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the literature reveals an altered pattern of melatonin secretion after anesthesia and surgery. 1 It is possible that pathological variation in melatonin levels or a disturbed circadian rhythm may modify the predisposition, severity, course, or outcome of postoperative complications, especially postoperative delirium, which is multifactorial.…”
Section: To the Editormentioning
confidence: 99%
“…1 Delirium and perioperative sleep disturbance are potentially linked -either as predisposing factors or as symptoms of one another. Thus, restoring normal sleeping patterns with a substance that is capable of resynchronizing circadian rhythm may possibly reduce the incidence of postoperative delirium or improve its outcome.…”
Section: To the Editormentioning
confidence: 99%
“…This is the situation in spite of the fact that the field of chronobiology has contributed significantly to the understanding of the pathophysiologic mechanisms of disease, diagnostics, and effective and safer treatment through chronotherapeutics-the timing according to circadian or other biological rhythms of pharmaceutical and other treatment interventions-thus benefiting the clinical practice of many medical specialties, including allergy, endocrinology, gastroenterology, internal medicine, neurology, pneumology, rheumatology, oncology, psychiatry, as well as occupational, reproductive, sleep, and sports medicine Atkinson et al, 2009;Axelsson et al, 2008;Biggi et al, 2008;Bougard et al, 2009aBougard et al, , 2009bBruguerolle, 2008;Burioka et al, 2008;Burkhart & Phelps, 2009;Camerino et al, 2008;Cariou et al, 2008;Costa & Di Milia, 2008;Coudert et al, 2008;Danilenko et al, 2008;Dispersyn et al, 2008;Edwards et al, 2008;Esquirol et al, 2009;Ferguson et al, 2008;Fietze et al, 2009;Folkard, 2008aFolkard, , 2008bGander et al, 2008aGander et al, , 2008bGrundy et al, 2009;Harma et al, 2008;Ingre et al, 2008;Iskra-Golec & Smith, 2008;Kantermann & Roenneberg, 2009;Kloog et al, 2008;Larsson et al, 2008Larsson et al, , 2009Lee et al, 2008;Lericollais et al, 2009;Lin et al, 2009;McLaughlin et al, 2008;Monk e...…”
Section: Introductionmentioning
confidence: 99%