“…[123][124][125] Intravenous anesthetics, including etomidate, propofol, and barbiturates, enhance the GABA A receptor function, and this effect contributes to hypnosis, immobility, and memory blockade. 105,108,111,114,126,127 The halogenated volatile anesthetics (isoflurane, sevoflurane, and desflurane) also enhance GABA A receptor function, although these drugs appear to be less selective for GABA A receptors than most intravenous anesthetics. 105,128 Studies using site-directed mutagenesis suggest that GABA A receptors are not the sole mediators of volatile anesthetics.…”