General and abdominal obesity trajectories across adulthood, and risk of prostate cancer: results from the PROtEuS study, Montreal, Canada

Vallières, Eric; Mésidor, Miceline; Roy-Gagnon, Marie-Hélène; Richard, Hugues; Parent, Marie‐Élise

doi:10.1007/s10552-021-01419-z

Cited by 4 publications

(4 citation statements)

References 56 publications

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“…Patients with chronic inflammatory diseases are at an increased risk of developing cancer. Both diabetes mellitus and obesity (particularly abdominal obesity) are associated with systemic chronic inflammation and with intermediate- and high-risk prostate cancer [ 3 , 4 , 74 , 75 ]. TWIST1 is a key mediator of both EndMT and EMT and is highly expressed in both obesity and prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis is especially concerning for patients with other existing co-morbidities, especially obesity. Multiple studies have shown that the incidences of metastatic disease and poor outcomes are significantly greater for obese men [ 3 , 4 ]. Despite advances in cancer research, management of metastatic prostate cancer is clinically challenging with significantly poorer outcomes [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients with chronic inflammatory diseases are more predisposed to the development of cancer [ 19 , 20 ]. Abdominal obesity in particular is associated with an increased risk of aggressive prostate cancer [ 4 ]. The obese adipose environment is characterized by chronic inflammation driven in part by increased macrophage infiltration and elevated cytokine and adipokine expression [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Adipose Tissue-Derived Extracellular Vesicles Contribute to Phenotypic Plasticity of Prostate Cancer Cells

Mathiesen¹,

Haynes²,

Huyck³

et al. 2023

IJMS

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Metastatic prostate cancer is one of the leading causes of male cancer deaths in the western world. Obesity significantly increases the risk of metastatic disease and is associated with a higher mortality rate. Systemic chronic inflammation can result from a variety of conditions, including obesity, where adipose tissue inflammation is a major contributor. Adipose tissue endothelial cells (EC) exposed to inflammation become dysfunctional and produce a secretome, including extracellular vesicles (EV), that can impact function of cells in distant tissues, including malignant cells. The aim of this study was to explore the potential role of EVs produced by obese adipose tissue and the ECs exposed to pro-inflammatory cytokines on prostate cancer phenotypic plasticity in vitro. We demonstrate that PC3ML metastatic prostate cancer cells exposed to EVs from adipose tissue ECs and to EVs from human adipose tissue total explants display reduced invasion and increased proliferation. The latter functional changes could be attributed to the EV miRNA cargo. We also show that the functional shift is TWIST1-dependent and is consistent with mesenchymal-to-epithelial transition, which is key to establishment of secondary tumor growth. Understanding the complex effects of EVs on prostate cancer cells of different phenotypes is key before their intended use as therapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adipose Tissue-Derived Extracellular Vesicles Contribute to Phenotypic Plasticity of Prostate Cancer Cells

Mathiesen¹,

Haynes²,

Huyck³

et al. 2023

IJMS

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“…Biopsy is then justifies ethically, on the medical side. A third method consists to random controls from frequency-matched to cases by age range in general men population [4].…”

Section: Introductionmentioning

confidence: 99%

Endemic statistical paradoxes in epidemiologic studies distort knowledge on prostate cancer: mitigation and caution of fallacies in prostate cancer causal epidemiological studies

Cussenot

Fromont

Cancel‐Tassin

et al. 2023

Current Opinion in Urology

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Purpose of review Many studies on epidemiology of prostate cancer (PCa) are based on a diagnosis of PCa using PSA (prostate-specific antigen) level. However, biases can distort the interpretation of the results, which in turn limits policy and decision making on public health prevention strategies or clinical guidelines. The main confusion is to interpret the posterior probability of the outcome following the exposure as a change in the prevalence of the disease outcome, whereas this change reflects only the predictive values of the PSA test induced by the exposure of interest. Recent findings Many studies report potential causal factors involved in PCa risk. However, the lack of integration of how physiological changes in PSA values are associated with the exposures being investigated, they explain in part contradictory and controversial results on PCa risk factors in the literature. Summary A strategy to perform case--control studies based on PSA stratification is suggested to avoid misinterpretation related to PSA misclassification. Real data are analysed, and we show that we can exploit the mechanism of selection biases using different modalities of controls recruitment based on biomarker stratification to distinguish real from false causal factors.

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2D:4D digit ratio as a potential marker for prostate cancer risk

Kouam,

Nicolau,

Rousseau

et al. 2024

Cancer Epidemiology

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General and abdominal obesity trajectories across adulthood, and risk of prostate cancer: results from the PROtEuS study, Montreal, Canada

Cited by 4 publications

References 56 publications

Adipose Tissue-Derived Extracellular Vesicles Contribute to Phenotypic Plasticity of Prostate Cancer Cells

Adipose Tissue-Derived Extracellular Vesicles Contribute to Phenotypic Plasticity of Prostate Cancer Cells

Endemic statistical paradoxes in epidemiologic studies distort knowledge on prostate cancer: mitigation and caution of fallacies in prostate cancer causal epidemiological studies

2D:4D digit ratio as a potential marker for prostate cancer risk

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