Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss

Abstract

These findings suggest that the common rs4646 C allele, which has been associated previously with higher circulating oestrogen levels, might be associated with predisposition to FPHL.

Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

“…While the findings of Yip et al [15] pointed out that the rs4646 allele positively correlates with FPHL in Caucasian patients, our study showed that there was no statistical significance for the expression of rs4646 between the FPHL patient group (A = 111 and C = 289) and the control group (A = 116 and C = 284, p = 0.695). Additionally, consistent with the negative results of the study of Redler et al [28] on the CYP19A1 gene of rs4646 in British and German FPHL patients, we demonstrated that there is no statistically significant difference (p = 0.871) in the gene pattern between our tested FPHL patient group (AA = 16, AC = 79, and CC = 105) and the control group (AA = 16, AC = 84, and CC = 100).…”

“…In other studies, no association was found between steroid 5α-reductase isoform genes or sex steroid hormone receptors and FPHL [27]. Moreover, an Australian genome-wide association study suggested that the aromatase gene (CYP19A1) may contribute to FPHL, but this was not confirmed in another study [15,28]. …”

“…The CYP19A1 gene plays a critical role in regulating androgen metabolism; thus, CYP19A1 research has become a hot topic in the diagnosis of breast cancer, polycystic ovary syndrome, and acne, all of which are sex hormone-associated clinical challenges [13,14]. An Australian genome-wide association study on the CYP19A1 gene demonstrated that CYP19A1 single nucleotide polymorphisms (SNPs) may be associated with FPHL, and the authors stressed the need for replicative studies to confirm their findings [15]. We thereupon conducted this study to explore the association of CYP19A1 gene SNPs with FPHL in a Chinese Han population.…”

Selected variants of the steroid‐5‐alpha‐reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

“…On the basis of a report of elevated aromatase levels in the skin of women with FPHL (23), androgens are assumed to act via a distinct mechanism, in contrast to male AGA. Aromatase, which is encoded by CYP19A1, converts androgens to oestrogens in the scalp hair follicles (24). Yip et al (24) performed a gene-wide association study of FPHL and CYP19A1 and reported borderline association for three variants.…”

A comparative study of treatment modalities in female androgenetic alopecia

“…2 Testosterone is converted to DHT with the help of the enzyme 5α-reductase. Deficiency of this enzyme has been implicated in the development of AGA.…”