Gene transcription of TLR2, TLR4, LPS ligands and prostaglandin synthesis enzymes are up-regulated in canine uteri with cystic endometrial hyperplasia–pyometra complex

Silva, E.; Leitão, Sara; Henriques, Sofia; Kowalewski, Mariusz P.; Hoffmann, Bernd; Ferreira‐Dias, Graça; Lopes-da-Costa, Luís; Mateus, L.

doi:10.1016/j.jri.2009.10.004

Cited by 61 publications

(56 citation statements)

References 39 publications

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“…KLF5 expression can be induced by a variety of oncogenic and proinflammatory factors, such as LPS (38), TNF␣ (39), TPA (3,40), and so on. These proinflammatory stimuli also induce mPGES1 (10,17,41). We also showed that KLF5 is essential for the induction of mPGES1 by TPA (Fig.…”

Section: Discussionsupporting

confidence: 65%

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer

Xia

Wang

Chen

et al. 2013

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 65%

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer

Xia

Wang

Chen

et al. 2013

Journal of Biological Chemistry

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“…As prevention against pathogen invasion the female genital system developed appropriate immune mechanisms. Innate immunity represents the most universal and the most rapid protective mechanism upon contact with pathogens (Silva et al 2010).…”

Section: Immunological Overlook On Endometritispyometramentioning

confidence: 99%

“…TLR receptors reside on the surface of epithelial cells in, among other locations, the intestines, respiratory tract, and on macrophages. Their presence was detected also on both types of endometrial cells (epithelial and sublayer cells) in humans and in cattle (Silva et al 2010). Out of thirteen membrane TLR receptors identified until now in mammals, TLR2 and TLR4 receptors have been most completely characterised as beingrelated to innate immunity to bacteria.…”

Section: Immunological Overlook On Endometritispyometramentioning

confidence: 99%

Endometritis and pyometra in bitches: a review

Kempisty¹,

Bukowska²,

Woźna³

et al. 2013

Vet. Med. - Czech

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Endometritis-pyometra is the most frequent and complex pathology in domestic bitches. This process involves several immunological changes as well as molecular mechanisms responsible for inflammation in the female uterus. The various clinical stages of pyometra are associated with various symptoms. In this review, several aspects are described, including physiological and pathological mechanisms as well as molecular changes which take place during induction of endometritis-pyometra. The authors also highlight the important role of growth factors and their receptors in this process. It is well known that pyometra is a compound process which mainly involves immunological changes during inflammation. However, this review presents a new overview of this process, which includes changes at the molecular level, e.g., the altered expression of genes crucial for the development of this disease. Although pyometra is the most frequent disease of the reproductive tract in bitches, the molecular basis of this process is still not entirely understood.

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“…Therefore, activation of TLRs can induce both physiological and pathological processes, including pro/anti-inflammatory processes (Kannaki et al, 2011). In the reproductive system, TLRs participate in ovulation, fertilization, placental function, trophoblast invasion, parturition, and protection of the reproductive tract from pathogens (Horne et al, 2008;Kannaki et al, 2011;Koga and Mor 2008;Silva et al, 2010). They also allow communication between many other components of the immune system (Koga and Mor 2008).…”

Section: Introductionmentioning

confidence: 99%

“…In bovine endometrium, TLRs play roles in the prevention of endometrial infection with microorganisms as they are expressed on epithelial cells of the endometrium (Davies et al, 2008). When TLR signaling is induced by appropriate signal molecules, many downstream targets of TLRs, including IL4, IL8, COX2, and TNFα, are regulated (Horne et al 2008;Silva et al 2010). Since the expression of many pro/anti-inflammatory molecules is affected during formation and regression of the CL (Skarzynski and Okuda 2010), the expression of TLRs may play critical roles in regulating the changing physiology of the CL.…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor 2 and 4 expression in the bovine corpus luteum during the different stages of the estrous cycle

Atlı¹,

Köse²,

Kaya³

et al. 2017

Anim Reprod

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The aim of this study was to elucidate the presence of components of the innate immune system in the bovine corpus luteum (CL) by detecting the expression and cell-specific localization of TLR2 and TLR4 during different stages of the estrous cycle in a control study design. Bovine CL samples were collected from a local slaughterhouse and assigned to three groups as follows: developing CL (dCL; n = 6, approx. days 3-6), mature CL (mCL; n = 5, approx. days 8-12), and regressing CL (rCL; n = 5, approx. days 17-19). An upregulation of TLR2 mRNA was detected only in rCL (P < 0.05). Localization of the TLR2 protein was particularly apparent in luteal cells and a prominent immunofluorescent signal corresponding to TLR2 was detected only in rCL. TLR4 mRNA were higher in mCL and rCL compared to dCL (P < 0.05). The presence of the TLR4 protein in bovine CL was clearly detected in the luteal cells of both mCL and rCL. The results of this study suggest a role for TLRs in the development, maintenance, and regression of bovine CL. TLR signaling mediated pathway in luteal cells may involve in the regression of CL via regulation of TLR2 and TLR4.

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Gene transcription of TLR2, TLR4, LPS ligands and prostaglandin synthesis enzymes are up-regulated in canine uteri with cystic endometrial hyperplasia–pyometra complex

Cited by 61 publications

References 39 publications

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer

Endometritis and pyometra in bitches: a review

Toll-like receptor 2 and 4 expression in the bovine corpus luteum during the different stages of the estrous cycle

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