“…Although genetic factors play a role in various NDD [Rocchi et al, 2003;Cordato and Chan, 2004] and are a major current focus of research, occupational and environmental factors contribute to NDD [Semchuk et al, 1992;Seidler et al, 1996;Sobel et al, 1996;Strickland et al, 1996;Davanipour et al, 1997;Liou et al, 1997;McGuire et al, 1997;Feychting et al, 1998;Gorell et al, 1998;Hock et al, 1998;Hubble et al, 1998;Johansen and Olsen, 1998;Savitz et al, 1998a;Tsui et al, 1999;Migliore and Coppede, 2002]. Mounting evidence suggests there are multiple, disparate contributing mechanisms such as oxidative damage, aberrant calcium homeostasis, metabolic compromise, amyloid precursor protein mismetabolism, and neuronal stress.…”