Gene therapy of the ischemic lower limb — Therapeutic angiogenesis

Bobek, Vladimír; Taltynov, Oliver; Pintérová, Daniela; Kološtová, Katarína

doi:10.1016/j.vph.2006.03.009

Cited by 40 publications

(39 citation statements)

References 133 publications

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“…Therefore, inhibitory therapy for angiogenesis has been developed as a novel therapeutic strategy for these diseases (11). On the other hand, it has recently been shown that stimulatory therapy for angiogenesis is effective in ischemic vascular disorders as well as ischemic heart disease by inducing formation of collaterals (12,13).…”

mentioning

confidence: 99%

All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling

et al. 2007

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A natural retinoid all-trans retinoic acid (ATRA) regulates a variety of important cellular functions via retinoic acid receptor (RAR). ATRA has therapeutically been used against various malignancies including acute promyelocytic leukemia. Recently ATRA has also been recognized to be beneficial against atherosclerotic vascular disorders. However, its effects on angiogenesis remain controversial. We therefore examined ATRA effects on in vitro angiogenesis in terms of capillary-like tube formation using human umbilical vein endothelial cells (HUVECs)/normal human dermal fibroblast (NHDF) coculture. ATRA as well as RAR agonist Am80 significantly induced capillary-like tube formation. The ATRA-induced tube formation was inhibited by coincubation with RAR antagonist LE540/LE135. HUVEC proliferation, but not its migration, was also induced by ATRA. The ATRA-induced tube formation was completely abolished by coincubation with vascular endothelial growth factor (VEGF) neutralizing antibody or with VEGF receptor (VEGFR)-2 (KDR) neutralizing antibody, but not VEGFR-1 (Flt-1) neutralizing antibody. ATRA and Am80 induced VEGF secretion in the coculture as well as VEGF secretion/mRNA expression in NHDFs. Transcription activity of human VEGF gene promoter in NHDFs was stimulated by ATRA, which was augmented by RAR overexpression. ATRA also induced VDGFR-2/KDR mRNA expression in HUVECs. Moreover, ATRA-induced secretion of hepatocyte growth factor as well as angiopoietin-2 in the coculture. Taken together, ATRA may have induced angiogenesis via RAR mainly by stimulation of HUVEC proliferation and enhancement of endogenous VEGF signaling and in part by induction of hepatocyte growth factor and angiopoietin-2 production. Retinoids may therefore be potential candidates for therapeutic angiogenesis against ischemic vascular disorders.

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confidence: 99%

All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling

et al. 2007

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“…To diminish these risks of side effects, many efforts have been made to deliver the arteriogenic drugs locally [24], rather than intravascularly [18,30]. Current research predicts future methods to deliver these drugs through therapeutic devices such as stents.…”

Section: Angiogenesismentioning

confidence: 99%

Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery

Struthers¹

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“…Hence, they are used only in treatments administered via injection or gene transfection approaches. [1][2][3] Therefore, we synthesized the first low-molecularweight angiogenesis promoter, 2-chloro-carbocyclic oxetanocin A (2-Chloro-C.OXT-A; COA-Cl, 1a, racemate, Fig. 1), [4][5][6][7][8] with a molecular weight (MW) of 284 that is suitable for pharmaceutical use via percutaneous and transmucosal absorption.…”

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confidence: 99%

Synthesis and Evaluation of Novel Cyclopropane Nucleoside as Potential Tube Formation Agents

Sakakibara

Igarashi

Takata

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Five novel nucleoside analogs with mono or bis-hydroxymethylated cyclopropane rings at the N 9 -position of the 2-chloroadenine moiety (2-chloro-carbocyclic oxetanocin A [COA-Cl] analog) were synthesized and evaluated using human umbilical vein endothelial cells. All the prepared compounds (2a-e) showed good to moderate activity with angiogenic potency. cis-2′-(Hydroxymethyl)cycloprop-1′-yl derivative (2b) at 100 µM had greater angiogenic activity than the other compounds did, with relative tube areas of 2.71 0.45 (mean standard deviation (S.D.)), which was superior to the potency of COA-Cl (2.30 0.59).

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Gene therapy of the ischemic lower limb — Therapeutic angiogenesis

Cited by 40 publications

References 133 publications

All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling

All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling

Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery

Synthesis and Evaluation of Novel Cyclopropane Nucleoside as Potential Tube Formation Agents

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