Gene therapy for cardiovascular diseases in China: basic research

Deng, Jiali; Guo, Mengying; Li, Guoping; Xiao, Junjie

doi:10.1038/s41434-020-0148-6

Cited by 12 publications

(9 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two microRNAs from the opposite side of the pre-microRNA name−3p or−5p (55). In recent years, studies have showed that microRNAs play essential roles in the pathogenesis of muscle atrophy induced by heart failure (56). The expression of miR-23a in muscle atrophy was less than controls, and resistance exercise increased the levels of miR-23a and miR-27a.…”

Section: Roles Of Microrna In Muscle Atrophy Induced By Heart Failurementioning

confidence: 99%

Current Studies and Future Directions of Exercise Therapy for Muscle Atrophy Induced by Heart Failure

Liu

Gao

Deng

et al. 2020

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Muscle atrophy is a common complication of heart failure. At present, there is no specific treatment to reverse the course of muscle atrophy. Exercise training, due to the safety and easy operation, is a recommended therapy for muscle atrophy induced by heart failure. However, the patients with muscle atrophy are weak in mobility and may not be able to train for a long time. Therefore, it is necessary to explore novel targets of exercise protection for muscle atrophy, so as to improve the quality of life and survival rate of patients with muscular atrophy induced by heart failure. This article aims to review latest studies, summarize the evidence and limitations, and provide a glimpse into the future of exercise for the treatment of muscle atrophy induced by heart failure. We wish to highlight some important findings about the essential roles of exercise sensors in muscle atrophy induced by heart failure, which might be helpful for searching potential therapeutic targets for muscle wasting induced by heart failure.

show abstract

Section: Roles Of Microrna In Muscle Atrophy Induced By Heart Failurementioning

confidence: 99%

Current Studies and Future Directions of Exercise Therapy for Muscle Atrophy Induced by Heart Failure

Liu

Gao

Deng

et al. 2020

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…With the acceleration of population aging, prevalence of MI patients will continue to increase [3] . Although the increasingly developed medical technology and reperfusion therapy post-MI can save patients' lives and improve clinical symptoms [4] , it is still unable to fundamentally reverse or terminate the further development of heart failure post-MI. Therefore, it is urgent to develop novel strategies to attenuate post-MI remodeling and heart failure.…”

Section: Introductionmentioning

confidence: 99%

Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction

et al. 2021

Self Cite

View full text Add to dashboard Cite

“…Non‐viral gene complexes are administered by intravenous injection, [ 6 ] intramuscular injection, [ 7 ] intradermal injection, [ 8 ] mucosal delivery, [ 9 ] and transdermal delivery. [ 10 ] Adopting a non‐intravenous administration approach could ensure that gene complexes effectively escape nuclease degradation and phagocytosis by the reticuloendothelial system.…”

Section: Introductionmentioning

confidence: 99%

Efficient Gene Delivery Based on Guanidyl‐Nucleic Acid Molecular Interactions

Wang

Song

Wang

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Low transfection efficacy of non-viral gene vectors restricts their applications. In this paper, N 1 ,N 3-dicarbamimidoyl-5-methylisophthalamide (BGG) is designed as a functional group, in which two guanidyls are located at the meta positions of an aryl ring. BGG is conjugated with PAMAM G5 (G5-BGG) and G5-BGG/DNA complex is dispersed into a polyvinyl alcohol (PVA) hydrogel for local injection. Molecular docking, NMR, IR and Isothermal titration calorimetry (ITC) experiments demonstrate that G5-BGG has multiple molecular interactions with nucleic acids, which yield high binding affinity toward nucleic acids. Interestingly, the in vitro transfection efficiency and serum stability of G5-BGG are significantly improved when the BGG modification ratio is just one. The integrated G5-BGG/DNA complex is released from a PVA hydrogel sustainably, crosses the cell membrane and escapes from endosome/lysosome. After local injection only once, these features of the G5-BGG/DNA-loaded PVA hydrogel are found to improve antitumor efficiency in vivo, and antitumor efficiency is significantly better than PEI 25K. The results confirm that BGG is a potential group for developing non-viral gene vectors with high transfection efficacy.

show abstract

Gene therapy for cardiovascular diseases in China: basic research

Cited by 12 publications

References 94 publications

Current Studies and Future Directions of Exercise Therapy for Muscle Atrophy Induced by Heart Failure

Current Studies and Future Directions of Exercise Therapy for Muscle Atrophy Induced by Heart Failure

Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction

Efficient Gene Delivery Based on Guanidyl‐Nucleic Acid Molecular Interactions

Contact Info

Product

Resources

About