Gene therapy and its implications in Periodontics

Mahale, Swapna; Dani, Nitin; Ansari, Shumaila; Kale, Triveni

doi:10.4103/0972-124x.51886

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Table 1 shows summary of extracted data. 5,7,[16][17][18][19][20][21][22][23][24][25][26][27] lIMItAtIon o f crIspr/cAs 9 technology…”

Section: In Pedodonticsmentioning

confidence: 99%

“…Multiple rounds of gene transfer or stable integration of therapeutic genes into host DNA offer potential solutions for prolonged effects, but these approaches raise concerns about possible undesirable side effects and unpredictable genomic modifications. 7,26 conclusIon The field of gene therapy, particularly with the advancements brought about by the CRISPR/Cas system, holds significant promise for revolutionizing dentistry. Our review, conducted through a comprehensive literature search, highlighted the current understanding of gene therapy and CRISPR/Cas technology in dentistry.…”

Section: Difficulties I N Gene Transfermentioning

confidence: 99%

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Gene Therapy and CRISPR/Cas Technology in Dentistry: A Review

Marimuthu,

Subramani,

Deepika

et al. 2024

Dental Journal of Advance Studies

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Background:The evolution of gene therapy, conceptualized in the 1960s, reached a pivotal moment in [1989][1990] with the approval of the first human clinical studies. Gene therapy, as defined by the US Food and Drug Administration (FDA), involves the administration of genetic material via nucleic acids, viruses, or genetically engineered microorganisms. This review explores the historical development and current landscape of gene therapy, focusing on its applications in dentistry. Materials and methods:A comprehensive narrative literature search, utilizing PubMed, MEDLINE, Scopus, and Web of Science databases, was conducted. Keywords and MeSH terms related to gene therapy, CRISPR/Cas technology, and dentistry were employed. Inclusion criteria encompassed English-language publications from the last 10 years, specifically focusing on the gene therapy or CRISPR/Cas applications in dentistry. Data synthesis involved critical appraisal and extraction of relevant information. Results: Gene transfer, a cornerstone of gene therapy, involves modifying defective genes through the injection of genetically modified vectors into target cells, either in vivo or ex vivo. Various methods, including physical (electroporation, microinjection) and chemical (calcium phosphate, liposome) approaches, facilitate gene modification. Dentistry applications range from addressing diseases such as squamous cell carcinoma and Sjogren's syndrome to enhancing bone regeneration, implants, and managing chronic pain. Conclusion:The potential of gene therapy and CRISPR/Cas technology in dentistry is vast, offering innovative, personalized therapeutic interventions. However, challenges such as ethical considerations and the need for long-term efficacy studies must be addressed to ensure the transformative impact of these technologies on oral healthcare practices. The future promises a paradigm shift in dental care, with gene therapy leading the way towards more effective and targeted treatments.

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“…Table 1 shows summary of extracted data. 5,7,[16][17][18][19][20][21][22][23][24][25][26][27] lIMItAtIon o f crIspr/cAs 9 technology…”

Section: In Pedodonticsmentioning

confidence: 99%

Section: Difficulties I N Gene Transfermentioning

confidence: 99%

Gene Therapy and CRISPR/Cas Technology in Dentistry: A Review

Marimuthu,

Subramani,

Deepika

et al. 2024

Dental Journal of Advance Studies

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“…Wherever this kind of durability is necessary, the therapeutic material must continue to work for the specified time. According to reports, there are two ways to accomplish this: either use numerous rounds of gene therapy to keep the therapeutic genes active for a longer period, or combine the therapeutic genes [46]. Targeting the FGF/FGFR pathway with biological therapies can result in an excellent prognosis.…”

Section: Future Directions and Researchmentioning

confidence: 99%

Unraveling the Complexity of Apert Syndrome: Genetics, Clinical Insights, and Future Frontiers

Kumari,

Saleh,

Taslim

et al. 2023

Cureus

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Apert syndrome (AS), also known as type I acrocephalosyndactyly, is a rare congenital condition characterized by craniosynostosis resulting from missense mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. This comprehensive review delves into AS, covering its clinical manifestations, genetics, diagnosis, medical management, psychosocial considerations, and future research directions. AS presents with distinct features, including a brachycephalic skull, midface hypoplasia, and limb anomalies such as syndactyly. It follows an autosomal dominant inheritance pattern with mutations in the FGFR2 gene. Prenatal diagnosis is possible through advanced imaging techniques and molecular testing. The multidisciplinary approach to AS management involves surgical interventions, orthodontics, and psychological support. Although no curative treatment exists, early interventions can significantly improve function and aesthetics. The quality of life for AS patients is influenced by psychosocial factors, necessitating comprehensive support for both patients and their families. Future research directions include gene therapy, understanding cellular responses to FGFR2 mutations, and addressing genetic heterogeneity. Collaborative efforts are vital to advancing knowledge about AS and its genetic underpinnings. Overall, this review serves as a valuable resource for healthcare professionals, educators, and researchers, contributing to a deeper understanding of AS and facilitating advancements in diagnosis and treatment.

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“…U.S. Food and Drug Administration defines gene therapy “as a technique to modify the host genes, or manipulate the expression of a gene, or change the host cell biological properties for therapeutic use” There are several approaches to gene therapy. The most common approach is the replacement of a non-functional gene by insertion of a normal gene within the genome at a nonspecific site [ 1 ]. Mutated, defective genes that cause disease can be silenced or healthy genes that help prevent disease could be turned on via gene editing [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Oncolytic virus-based suicide gene therapy for cancer treatment: a perspective of the clinical trials conducted at Henry Ford Health

et al. 2023

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Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient’s cells to improve cancer therapy and potentially find a cure is gaining popularity. Currently, there are 12 gene therapy products approved by US-FDA, EMA and CFDA for cancer management, these include Rexin-G, Gendicine, Oncorine, Provange among other. The Radiation Biology Research group at Henry Ford Health has been actively developing gene therapy approaches for improving clinical outcome in cancer patients. The team was the first to test a replication-competent oncolytic virus armed with a therapeutic gene in humans, to combine this approach with radiation in humans, and to image replication-competent adenoviral gene expression/activity in humans. The adenoviral gene therapy products developed at Henry Ford Health have been evaluated in more than 6 preclinical studies and evaluated in 9 investigator initiated clinical trials treating more than100 patients. Two phase I clinical trials are currently following patients long term and a phase I trial for recurrent glioma was initiated in November 2022. This systematic review provides an overview of gene therapy approaches and products employed for treating cancer patients including the products developed at Henry Ford Health.

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Gene therapy and its implications in Periodontics

Cited by 8 publications

References 24 publications

Gene Therapy and CRISPR/Cas Technology in Dentistry: A Review

Gene Therapy and CRISPR/Cas Technology in Dentistry: A Review

Unraveling the Complexity of Apert Syndrome: Genetics, Clinical Insights, and Future Frontiers

Oncolytic virus-based suicide gene therapy for cancer treatment: a perspective of the clinical trials conducted at Henry Ford Health

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