2013
DOI: 10.1111/anec.12048
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Gene‐Specific Effect of Beta‐Adrenergic Blockade on Corrected QT Interval in the Long QT Syndrome

Abstract: The effect of beta-adrenergic blockade on QTc duration is different in LQT1 and LQT2 patients. Our data suggest that, in LQT1 patients, the well-known positive effect of beta-blockade might be associated with a prolongation of QTc duration. The mechanisms of beta-blockade protection may be different in LQT1 and in LQT2 patients.

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Cited by 8 publications
(2 citation statements)
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“…Augmentation of sympathetic tone, such as exercise, is one of the important triggers of cardiac events and can be prevented by beta-blocking agents. Attenuation of transmural dispersion of repolarization and reduction of QT interval have been suggested as mechanisms of beta-blocking protection despite some controversies [ 33 35 ]. In LQT2, the effectiveness of beta-blockers has been thought to be less than that in LQT1 [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…Augmentation of sympathetic tone, such as exercise, is one of the important triggers of cardiac events and can be prevented by beta-blocking agents. Attenuation of transmural dispersion of repolarization and reduction of QT interval have been suggested as mechanisms of beta-blocking protection despite some controversies [ 33 35 ]. In LQT2, the effectiveness of beta-blockers has been thought to be less than that in LQT1 [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…All Holter recordings were 24-hour recordings (2 or 3 lead configuration) recorded from different clinical devices. The LQTS data was donated to the THEW 8 by the Hospital Lariboisière (Paris, France), 9, 10 while the recordings from healthy subjects were recorded during the Intercity Digital Electrocardiology Alliance project (IDEAL). 8 In addition to genetic testing, demographic data and cardiac events, i.e.…”
Section: Methodsmentioning
confidence: 99%