Gene signature of circulating platelet‐bound neutrophils is associated with poor prognosis in cancer patients

Lecot, Pacôme; Ardin, Maude; Dussurgey, Sébastien; Alcazer, Vincent; Moudombi, Lyvia; Abrantes, Manuela Pereira; Hubert, Margaux; Swalduz, Aurélie; Hernández-Vargas, Héctor; Viari, Alain; Caux, Christophe; Michallet, M

doi:10.1002/ijc.33991

Cited by 15 publications

(13 citation statements)

References 64 publications

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“…Interestingly, such a group of IFN‐stimulated TANs has also been identified in LC 74 and pancreatic cancer, 72 suggesting the conserved neutrophil subtypes in different disease conditions. Besides, Lecot et al 76 . reported that a subgroup of peripheral neutrophils that bind to neutrophil–platelet aggregates hold a higher capacity for chemotaxis and trans‐endothelial migration, which predicts dismal prognosis in solid cancers.…”

Section: Discussionmentioning

confidence: 99%

Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil

Peng

Xiao-yue

Liu

et al. 2023

Clinical & Translational Med

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Background The cellular dynamics in the tumour microenvironment (TME) along with non‐small cell lung cancer (NSCLC) progression remain unclear. Methods Multiplex immunofluorescence test detecting 10 immune‐related markers on 553 primary tumour (PT) samples of NSCLC was conducted and spatial information in TME was assessed by the StarDist depth learning model. The single‐cell transcriptomic atlas of PT (n = 4) and paired tumour‐draining lymph nodes (TDLNs) (n = 5 for tumour‐invaded, n = 3 for tumour‐free) microenvironment was profiled. Various bioinformatics analyses based on Gene Expression Omnibus, TCGA and Array‐Express databases were also used to validate the discoveries. Results Spatial distances of CD4+ T cells–CD38+ T cells, CD4+ T cells–neutrophils and CD38+ T cells–neutrophils prolonged and they were replaced by CD163+ macrophages in PT along with tumour progression. Neutrophils showed unique stage and location‐dependent prognostic effects. A high abundance of stromal neutrophils improved disease‐free survival in the early‐stage, whereas high intratumoural neutrophil infiltrates predicted poor prognosis in the mid‐to‐late‐stage. Significant molecular and functional reprogramming in PT and TDLN microenvironments was observed. Diverse interaction networks mediated by neutrophils were found between positive and negative TDLNs. Five phenotypically and functionally heterogeneous subtypes of tumour‐associated neutrophil (TAN) were further identified by pseudotime analysis, including TAN‐0 with antigen‐presenting function, TAN‐1 with strong expression of interferon (IFN)‐stimulated genes, the pro‐tumour TAN‐2 subcluster, the classical subset (TAN‐3) and the pro‐inflammatory subtype (TAN‐4). Loss of IFN‐stimulated signature and growing angiogenesis activity were discovered along the transitional trajectory. Eventually, a robust six neutrophil differentiation relevant genes‐based model was established, showing that low‐risk patients had longer overall survival time and may respond better to immunotherapy. Conclusions The cellular composition, spatial location, molecular and functional changes in PT and TDLN microenvironments along with NSCLC progression were deciphered, highlighting the immunoregulatory roles and evolutionary heterogeneity of TANs.

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Section: Discussionmentioning

confidence: 99%

Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil

Peng

Xiao-yue

Liu

et al. 2023

Clinical & Translational Med

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“…2 It is commonly found in several pathological disease states, such as severe infection, hyperimmunoglobulinemia, autoimmune diseases, and malignant tumors. [3][4][5][6] Leucoagglutination mostly involves neutrophils, resulting in pseudoneutropenia, then followed the lymphoagglutination and monocyte aggregation. 7 Hereditary elliptocytosis (HE) is one of the most common red cell membrane disorders, caused by a number of different gene mutations.…”

Section: E T T E R T O T H E E D I T O R Edta-dependent Leucoagglutin...mentioning

confidence: 99%

EDTA‐dependent leucoagglutination in a child with hereditary elliptocytosis and Mycoplasma pneumoniae infection

Li¹,

Meng

Song

et al. 2023

Pediatric Blood & Cancer

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“…Specific mechanisms are associated with tumor cell proliferation, apoptosis, and the immune microenvironment 240,241 . As study advances, researchers have shown that neutrophils undergo phenotype and functional remodulation under the influence of tumors and their microenvironment, playing a complicated role in tumor development and metastasis 242–244 . Besides protumor activity through protumor neutrophils, NETs, and various subsets associated with cancer process, neutrophils also exert antitumor functions via antitumor neutrophils, other derivatives, and subsets inhibiting cancer process (Figure 5).…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

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Gene signature of circulating platelet‐bound neutrophils is associated with poor prognosis in cancer patients

Cited by 15 publications

References 64 publications

Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil

Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil

EDTA‐dependent leucoagglutination in a child with hereditary elliptocytosis and Mycoplasma pneumoniae infection

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

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