Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2

“…The barrier function is significantly disrupted in Ahr -null mice, indicating that AHR plays a pivotal role in skin barrier integrity [35]. FLG is one of the major components of barrier proteins [23,36]. Loss-of-function mutation of FLG causes dry skin and is critically involved in the pathogenesis of atopic dermatitis [37,38,39].…”

“…Certain antioxidant phytochemicals also upregulate the expression of filaggrin (FLG), which plays a pivotal role in maintaining epidermal barrier function [19,20,21,23]. …”

146 Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

“…Given that our previous studies revealed that AHR activation induces FLG expression in NHEKs, 6 we determined whether AHR regulates the OVOL1 expression in NHEKs. OVOL1 expression was decreased in AHR-knockdown NHEKs transfected with AHR siRNA as compared with the cells transfected with control siRNA (Supplementary Figure S2A).…”

“…6,7 Activated AHR relocates from the cytoplasm to nucleus, and this action induces transcription of the target genes, such as CYP1A1, in NHEKs. Nonetheless, the precise mechanism by which AHR regulates FLG expression remains unclear.…”

T helper type 2 signatures in atopic dermatitis

“…30,66 Both agents are potent activators for the aryl hydrocarbon receptor (AHR), which is abundantly expressed in epidermal keratinocytes. 30,66,67 Notably, AHR is an upstream transcription factor for OVOL1/FLG and OVOL1/LOR signaling. 29,64,65 For example, soybean tar, Glyteer, activates AHR, which induces nuclear translocation of OVOL1 and upregulation of FLG and LOR expression.…”