Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae

Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease: Table 1

“…These results are similar to those reported among cohorts of pregnant women 5 6. In a non-pregnant cohort of 159 HIV-1-positive African–Americans, BV (Nugent's criteria) was associated with TLR1 rs5743612 (HR adjusted 1.56), TLR4 rs4986790 (HR adjusted 1.47), and TLR9 rs187084 (HR adjusted 1.52), while TLR2 rs1898830 was associated with BV diagnosed by Amsel's criteria (HR adjusted 1.89) 7.…”

“…Studies among pregnant women primarily of European ancestry, have not found significant associations between variants in the TLR1, TLR2, TLR4 and TLR6 genes and BV 5 6. An association between the BV-associated microbe, A vaginae , and a TLR1 variant was reported 5. By contrast, variants in the TLR1, TLR4 and TLR9 genes were associated with BV among 159 HIV-1-positive African–American adolescents 7.…”

“…Furthermore, genital mucosal fluids from women with BV induce TLR4 and TLR2 mRNA expression, NF-κB signalling, and inflammation in vitro 4. Studies among pregnant women primarily of European ancestry, have not found significant associations between variants in the TLR1, TLR2, TLR4 and TLR6 genes and BV 5 6. An association between the BV-associated microbe, A vaginae , and a TLR1 variant was reported 5.…”

Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients

“…The protocol for the DoPA strips is similar to the protocol for the MBL2-LiPA strips and has been applied in other studies [25][26][27].…”

Development of Intrauterine Infection Caused by Herpesviridae: A Role of C D14, Tlr2, Tlr6 Allelic Polymorphism

“…CD14 на поверхности фагоцита рас-познает лиганд микроорганизма и активирует TLR, которые в случае проникновения вируса индуцируют MyD88-независимый путь транс-дукции сигнала тревоги и приводит к продукции интерферонов. В зарубежной литературе описа-на корреляция тяжести течения внутриутробных инфекций с частотой точечной однонуклеотид-ной замены 159 C/T в гене CD14, Arg753 Gln в гене TLR2 и Ser249Pro в генеTLR6 [7][8][9][10][11]. Вышеописанное послужило предпосылкой для изучения роли полиморфизма генов системы врожденного иммунного ответа в развитии вну-триутробной инфекции.…”