Gene Polymorphisms of OPRM1 A118G and ABCB1 C3435T May Influence Opioid Requirements in Chinese Patients with Cancer Pain

Gong, Xiaodi; Wang, Jiong-Yi; Liu, Feng; Yuan, Hai-Hua; Zhang, Wenying; Guo, Yiwei; Jiang, Bin

doi:10.7314/apjcp.2013.14.5.2937

Cited by 49 publications

(42 citation statements)

References 48 publications

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“…However, when they measured using weight-surface area-adjusted-24h-opioids doses instead, TT homozygotes tended to require significantly lower opioids intake dosage than CC/CT carriers. [20]. In the study of Candiotti et al where C3435T was genotyped in 152 patients undergoing a nephrectomy, authors found an association between the ABCB1 polymorphism (C3435T) and inter individual variations in opioid consumption in the acute postoperative period after nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain

Nojkov

Карталов

Кузмановска

et al. 2016

Prilozi

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Background:The minimal effective analgesic concentration of opioids required for satisfactory analgesia may differ significantly among the patients. Genetic factors may contribute to the variable response to opioids by affecting their pharmacokinetics or pharmacodynamics. Methods: Ninety nine patients undergoing abdominal surgery with colorectal anastomosis because of colorectal carcinoma were enrolled in the present study. C34535T was genotyped in all subjects and the patients were divided into three groups according to their genotype: CC-wild type homozygous, CT-mutant heterozygous and TT-mutant homozygous. Intravenous fentanyl, patient controlled analgesia was provided postoperatively for pain control in the first 24 hour after surgery. Opioid consumption, pain scores and the adverse side effects were evaluated. Results: Our main result is that the patients in the CC genotype group consumed significantly more fentanyl (375.0 µg ± 43.1) than the patients in the TT group (295.0 µg ± 49.1) and the CT (356.4 µg ± 41.8) group in the treatment of postoperative pain. The patients in the TT group had lower VAS scores at 6h, 12h, 18 h and 24h postoperatively. There were no significant differences in the side effects among the three groups regarding the vomiting and the sedation score. The patients in the TT group had more frequently nausea score 1, than the patients in the other two groups. Conclusion: Our study indicates that the C3435T SNPs of the ABCB1 gene is associated with differences in the opioid sensitivity. The ABCB1 polymorphism may serve as an important genetic predictor to guide the acute pain therapy in postoperative patients.

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Section: Discussionmentioning

confidence: 99%

Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain

Nojkov

Карталов

Кузмановска

et al. 2016

Prilozi

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“…Another study found that a subject with the ABCB1 3435C>T homozygous genotype had a high maximum cerebrospinal fluid (CSF) concentration of morphine. The ABCB1 3435C>T allele has also been linked with higher morphine analgesia in cancer-related pain and lower morphine dose requirements in a mixed chronic pain population [19,20]. However, the role of ABCB1 in morphine PK is not well known.…”

Section: Introductionmentioning

confidence: 99%

ABCC3 and OCT1 Genotypes Influence Pharmacokinetics of Morphine in Children

et al. 2014

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Aim Large interindividual variability in morphine pharmacokinetics could contribute to variability in morphine analgesia and adverse events. Methods Influence of weight, genetic polymorphisms, race and sex on morphine clearance and metabolite formation from 220 children undergoing outpatient adenotonsillectomy was studied. A nonlinear mixed effects model was developed in NONMEM to describe morphine and morphine glucuronide pharmacokinetics. Results Children with ABCC3 −211C>T polymorphism C/C genotype had significantly higher levels of morphine-6-glucuronide and morphine-3-glucuronide formation (~40%) than C/T+T/T genotypes (p < 0.05). In this extended cohort similar to our earlier report, OCT1 homozygous genotypes (n = 13, OCT1*2–*5/*2–*5) had lower morphine clearance (14%; p = 0.06), and in addition complementing lower metabolite formation (~39%) was observed. ABCB1 3435C>T TT genotype children had lower levels of morphine-3-glucuronide formation though no effect was observed on morphine and morphine-6-glucuronide pharmacokinetics. Conclusion Our data suggest that besides bodyweight, OCT1 and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children.

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“…The prevalence and the severity of pain experienced by cancer patients depend upon several factors such as the stage, the site, and the region of metastasis related to the disease. In this respect, pain in cancer patients can be examined in three major groups, by cancer etiology, by anti-neoplastic treatment, and by cancer disease (Grond et al, 1996, Gong et al, 2013, Demir et al, 2013.…”

Section: Introductionmentioning

confidence: 99%

Cancer Pain Prevalence and its Management

Arslan¹,

Koca²,

Akar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Pain is a public health problem affecting more than half of cancer patients. Despite the success of the protocols currently used, pain cannot still be reduced satisfactorily in the large majority of patients. In order to improve pain management, all healthcare professionals involved with pain should have sufficient knowledge on pain assessment and treatment, and should inform patients to prevent patient-related barriers. In this compilation, the prevalence values and the treatment methods of cancer pain, and the barriers to pain management have been assessed.

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Gene Polymorphisms of OPRM1 A118G and ABCB1 C3435T May Influence Opioid Requirements in Chinese Patients with Cancer Pain

Cited by 49 publications

References 48 publications

Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain

Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain

ABCC3 and OCT1 Genotypes Influence Pharmacokinetics of Morphine in Children

Cancer Pain Prevalence and its Management

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