Gene polymorphisms and HLA-G expression in spontaneous abortions

García-Láez, V.; Serra, Vicente; Bellver, José; Ferro, Jaime; Vidal, C.; Santos, J.M. De los; Rubio, Mari Carmen; Martin, J. Lercher; Martı́nez, Carmen; Santos, María José de los

doi:10.1016/j.medre.2015.09.001

Cited by 2 publications

(3 citation statements)

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“…Moreover, maternal circulating sHLA-G levels in the second trimester were significantly lower in pregnant women with 18-trisomy fetuses (T18) and significantly higher in those with 21-trisomy fetuses (T21) compared to the normal controls ( 131 ), and it is inversely correlated with fetal microchimerism levels ( 132 ). Also, there are contrary results that the HLA-G expression is similar between samples of normal and abnormal karyotypes, and there is no association between the HLA-G polymorphisms and altered expression in reduced abortion and miscarriage groups ( 133 ). Schallmoser et al.…”

Section: Discussionmentioning

confidence: 86%

Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Zeng

2022

Front. Immunol.

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IntroductionHLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes. HLA-G polymorphism is associated with HLA-G expression and linked to pregnancy complications. However, the association of parental HLA-G polymorphisms with soluble HLA-G (sHLA-G) expression and their roles in recurrent implantation failure (RIF) is unclear. The study aims to systematically review the association of HLA-G polymorphisms with RIF, the association of sHLA-G expression with RIF, and the association of HLA-G polymorphisms with sHLA-G expressions in patients attending in-vitro fertilization (IVF) treatment.MethodsStudies that evaluated the association of HLA-G polymorphisms with RIF, the association between sHLA-G expression with RIF, and the association between HLA-G polymorphisms with sHLA-G expressions in patients attending IVF treatment were included. Meta-analysis was performed by random-effect models. Sensitivity analysis was performed by excluding one study each time. Subgroup analysis was performed based on ethnicity.ResultsHLA-G 14bp ins variant is associated with a lower expression of sHLA-G in seminal or blood plasma of couples attending IVF treatment. The maternal HLA-G*010101 and paternal HLA-G*010102 alleles are associated with RIF risk compared to other alleles. However, single maternal HLA-G 14bp ins/del polymorphism, HLA-G -725 C>G/T polymorphism, or circulating sHLA-G concentration was not significantly associated with RIF in the general population. HLA-G 14bp ins/ins homozygous genotype or ins variant was associated with a higher risk of RIF in the Caucasian population.DiscussionSpecific HLA-G alleles or HLA-G polymorphisms are associated with sHLA-G expression in couples attending IVF treatment. Several HLA-G polymorphisms may be related to RIF, considering different ethnic backgrounds. A combined genetic effect should be considered in future studies to confirm the association of HLA-G polymorphisms and sHLA-G expressions in relation to RIF.

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Section: Discussionmentioning

confidence: 86%

Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Zeng

2022

Front. Immunol.

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“…The expression of HLA molecules is not uniform along normal pregnancy. In the case of HLA-C, immunohistochemistry analysis of placental and decidual tissue samples at different stages of gestation showed a strong staining of EVT membranes at 5 weeks' gestation, while a decrease in staining intensity was evident from 12 weeks onwards; however, expression was high in fetal amniotic and chorion membranes of 38-week placenta [52]. Expression of HLA-G in pregnancy has been extensively studied.…”

Section: Expression Of Hla Class I Molecules and Successful Pregnancymentioning

confidence: 99%

“…Thus, high expression of HLA-G is associated with successful pregnancy, whereas low levels of HLA-G have been associated with pregnancy complications [54,55]. Indeed, polymorphisms in HLA-G, especially a 14-bp insertion/deletion polymorphism in exon 8 related to low HLA-G expression, have been associated not only with reduced success of in vitro fertilization treatment and pregnancy outcome, but also with lower birth weight and weight of the placenta [31,52,56] (Fig. 2).…”

Section: Expression Of Hla Class I Molecules and Successful Pregnancymentioning

confidence: 99%

Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications

Díaz‐Peña

Santos

Lucía

et al. 2019

J Assist Reprod Genet

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Pregnancy is a unique immunological situation in which a fetus-bearing paternal histocompatibility antigens can survive in a maternal environment without apparent rejection. To face this challenge, cells of the uterine immune system show characteristic changes in absolute number and composition during pregnancy. Particularly relevant to this process are uterine natural killer (uNK) cells and their cell surface receptors, killer immunoglobulin-like receptors (KIRs). The main purpose of this review is to outline the current body of knowledge on the involvement of KIRs in the complications of pregnancy. Implantation depends on the invasion of embryonic trophoblast cells into maternal uterine tissue and remodeling of the uterine spiral arterioles, which is essential for placental perfusion and successful pregnancy. The proper interaction between maternal KIRs and their ligands human leukocyte antigen (HLA) class I molecules, expressed by the extravillous trophoblast cells, is crucial in this process. KIRs are a complex family that includes both activator and inhibitory receptors. The activation profile is genetically determined in each individual and leads to diverse levels of functionality for NK and T cells on engagement with specific HLA class I molecules. An association between different KIR alleles and HLA molecules has been reported in pregnancy complications, supporting the idea of a relevant role of these receptors in successful pregnancy.

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Gene polymorphisms and HLA-G expression in spontaneous abortions

Cited by 2 publications

References 61 publications

Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications

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