1994
DOI: 10.1006/geno.1994.1555
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Gene Organization of the Pregnancy-Specific Glycoprotein Region on Human Chromosome 19: Assembly and Analysis of a 700-kb Cosmid Contig Spanning the Region

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Cited by 52 publications
(30 citation statements)
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“…Located at chromosome 19q13.2 within the cluster of CEA-related genes (Olsen et al, 1994), CEACAM1 is the most conserved member with one known gene in humans . This gene gives rise to alternatively spliced mRNA species with isoforms differing mostly in their cytoplasmic domains.…”
Section: Introductionmentioning
confidence: 99%
“…Located at chromosome 19q13.2 within the cluster of CEA-related genes (Olsen et al, 1994), CEACAM1 is the most conserved member with one known gene in humans . This gene gives rise to alternatively spliced mRNA species with isoforms differing mostly in their cytoplasmic domains.…”
Section: Introductionmentioning
confidence: 99%
“…The whole-genome mapping projects (Chumakov et al 1995;Hudson et al 1995) have produced contigs in 22q11 that differ from Collins et al (1995), and discrepancies can often be traced to problems with low copy repeats. The high-resolution YAC and cosmid map of chromosome 16 and 19 contains multigene families and noncoding repetitive sequences that also required special attention during contig assembly (see Olsen et al 1994;Ashworth et al 1995;Doggett et al 1995). The existence of low copy repeats such as those described here may interfere with production of sequence-ready maps and genomic DNA sequence in several regions of the human genome, and may require more detailed mapping methods to be applied.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, Stallings et al (1992) noted that repetitive sequences had resulted in apparent false overlaps in a cosmid contig on chromosome 16. A region of low copy repeats was also found on chromosome 19, but a modified fingerprinting method was able to resolve cosmids in this region (Olsen et al 1994). Repetitive DNA also leads to yeast artificial chromosome (YAC) instability (Neil et al 1990), which hampers the YAC mapping strategy.…”
mentioning
confidence: 99%
“…Carcinoembryonic antigen is part of the large immunoglobulin-like CEA gene family comprising as many as 31 genes , all located on chromosome 19q13.2 in humans (Olsen et al, 1994). Twenty of these genes are expressed in a variety of normal and tumor epithelial, hematopoietic cells and in placenta .…”
Section: Introductionmentioning
confidence: 99%