Gene Mutations in Gastrointestinal Stromal Tumors: Advances in Treatment and Mechanism Research
Lei Cao,
Wencong Tian,
Yongjie Zhao
et al.
Abstract:Although gastrointestinal stromal tumors (GISTs) has been reported in patients of all ages, its diagnosis is more common in elders. The two most common types of mutation, receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor a (PDGFRA) mutations, hold about 75 and 15% of GISTs cases, respectively. Tumors without KIT or PDGFRA mutations are known as wild type (WT)-GISTs, which takes up for 15% of all cases. WT-GISTs have other genetic alterations, including mutations of the succinate dehydr… Show more
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