“…In addition to pathways enriched in differentially expressed genes (Wnt, Notch, Serine biosynthesis; Evgrafov et al, 2017), we found that PI3K-Akt signaling has been identified as important in multiple studies of SCZ (Mao et al, 2009; Panaccione et al, 2013; Singh et al, 2013; Topol et al, 2015; Mulligan and Cheyette, 2016; Howell et al, 2017; Wang et al, 2017). Pathway analysis of GWAS data, performed by The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) showed enrichment of several GO terms, associated with neuron structure and histone H3-K4 methylation.…”