Gene locations may contribute to predicting gene regulatory relationships

Abstract

We propose that locations of genes on chromosomes can contribute to the prediction of gene regulatory relationships. We constructed a time-based gene regulatory network of zebrafish cardiogenesis on the basis of a spatio-temporal neighborhood method. Through the network, specific regulatory pathways and order of gene expression during zebrafish cardiogenesis were obtained. By comparing the order with locations of these genes on chromosomes, we discovered that there exists a reversal phenomenon between the order and order of gene locations. The discovery provides an inherent rule to instruct exploration of gene regulatory relationships. Specifically, the discovery can help to predict if regulatory relationships between genes exist and contribute to evaluating the correctness of discovered gene regulatory relationships.

Home Range Characteristics of the Released Female Milu (Père David’s Deer, Elaphurus davidianus) Population during Different Periods and Effects of Water Submersion in Dongting Lake, China

“…The results of this study were expected in October 2020. Results of the trial were reporteded according to the Consolidated Standards of Reporting Trials guidelines (Meng and Young, 2018).…”