2001
DOI: 10.1006/bbrc.2001.4913
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Gene Induction Pathways Mediated by Distinct IRFs during Viral Infection

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Cited by 161 publications
(163 citation statements)
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“…IRF-3 is constitutively expressed and activated post-translationally, whereas IRF-7 is regulated at the transcriptional level (reviewed by Nakaya et al, 2001). Servant et al (2001) recently demonstrated MV-induced IRF-3 activation, and in the present study we demonstrate MV-induced upregulation of the IRF-7 gene.…”
Section: Discussionsupporting
confidence: 77%
“…IRF-3 is constitutively expressed and activated post-translationally, whereas IRF-7 is regulated at the transcriptional level (reviewed by Nakaya et al, 2001). Servant et al (2001) recently demonstrated MV-induced IRF-3 activation, and in the present study we demonstrate MV-induced upregulation of the IRF-7 gene.…”
Section: Discussionsupporting
confidence: 77%
“…Those are: ISG15, ISG1-8, ISG56, ISG54, CXCL10, Viperin, NOXA, RANTES CXCL11, and USP18. [45][46][47][48] Induction of haptoglobin and antichymotrypsin ACT (SERPIN A3) by IKK⑀ can be presumably attributed to c/EBP␦ activation. 49,50 Some of the genes of the IKK⑀ transcriptome may be induced as secondary events through some transcription factors induced by IKK⑀.…”
Section: Resultsmentioning
confidence: 99%
“…45,46 The stimuli remain to be defined; however, IFN-a was reported expressing at low levels in normal or axenic mice. 47 Rapid stimulation of the Tolllike receptor causes IRF3 activation, IFN-b synthesis and signal transduction through the type I IFNAR.…”
Section: Discussionmentioning
confidence: 99%