Gene Expressions of the Dhb, Vtg, Arnt, CYP4, CYP314 in Daphnia magna Induced by Toxicity of Glyphosate and Methidathion Pesticides

Le, Thai-Hoang; Min, Jiho; Lee, Sung-Kyu; Kim, Yang-Hoon

doi:10.5772/31797

Pesticides in the Modern World - Pests Control and Pesticides Exposure and Toxicity Assessment 2011

DOI: 10.5772/31797

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Gene Expressions of the Dhb, Vtg, Arnt, CYP4, CYP314 in Daphnia magna Induced by Toxicity of Glyphosate and Methidathion Pesticides

Thai-Hoang Le¹,

Jiho Min²,

Sung-Kyu Lee³

et al.

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2015

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Roundup® exposure promotes gills and liver impairments, DNA damage and inhibition of brain cholinergic activity in the Amazon teleost fish Colossoma macropomum

et al. 2015

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Roundup Original® (RD) is a glyphosate-based herbicide used to control weeds in agriculture. Contamination of Amazon waters has increased as a consequence of anthropogenic pressure, including the use of herbicides as RD. The central goal of this study was to evaluate the toxic effects of RD on juveniles of tambaqui (Colossoma macropomum). Our findings show that biomarkers in tambaqui are organ specific and dependent on RD concentration. Alterations in gills structural and respiratory epithelium were followed by changes in hematological parameters such as concentration of hemoglobin, particularly in fish exposed to the higher concentration tested (75% of RD LC50 96 h). In addition, both RD concentrations affected the biotransformation process in gills of tambaqui negatively. Instead, liver responses suggest that a production of reactive oxygen species (ROS) occurred in fish exposed to RD, particularly in the animals exposed to 75% RD, as seen by imbalances in biotransformation and antioxidant systems. The increased DNA damage observed in red blood cells of tambaqui exposed to RD is in agreement with this hypothesis. Finally, both tested sub-lethal concentrations of RD markedly inhibited the cholinesterase activity in fish brain. Thus, we can suggest that RD is potentially toxic to tambaqui and possibly to other tropical fish species.

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Roundup® exposure promotes gills and liver impairments, DNA damage and inhibition of brain cholinergic activity in the Amazon teleost fish Colossoma macropomum

et al. 2015

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Gene Expressions of the Dhb, Vtg, Arnt, CYP4, CYP314 in Daphnia magna Induced by Toxicity of Glyphosate and Methidathion Pesticides

Cited by 1 publication

References 28 publications

Roundup® exposure promotes gills and liver impairments, DNA damage and inhibition of brain cholinergic activity in the Amazon teleost fish Colossoma macropomum

Roundup® exposure promotes gills and liver impairments, DNA damage and inhibition of brain cholinergic activity in the Amazon teleost fish Colossoma macropomum

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