Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes
Josh G. Chenoweth,
Carlo Colantuoni,
Deborah A. Striegel
et al.
Abstract:Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patter… Show more
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