Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly

Falch, Camilla Maria; Arlien-Søborg, Mai Christiansen; Dal, Jakob; Sundaram, Arvind; Michelsen, Annika; Ueland, Thor; Olsen, Linn Guro; Heck, Ansgar; Bollerslev, Jens; Jørgensen, Jens Otto Lunde; Olarescu, Nicoleta Cristina

doi:10.1093/ejendo/lvad031

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…Metrnβ is a novel secreted cytokine/myokine that has been implicated as immunoregulatory both in innate and acquired immunity. Current studies on Metrnβ have mainly focused on neurodevelopment, insulin resistance, beige fat thermogenesis, metabolism and inflammation related diseases [ 11 , 12 , 24 ]. To our knowledge, Metrnβ −/− mice exhibit inflammatory lesions in the uterus, kidneys and liver, and have increased susceptibility to LPS-induced sepsis [ 14 ], thereby implicating Metrnβ as playing regulatory roles in the resolution of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus

Zhang,

Cai,

et al. 2023

IJMS

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Systemic lupus erythematosus (SLE) is an auto-immune disease, the pathogenesis of which remains to be fully addressed. Metrnβ is a novel cytokine involved in the pathogenesis of inflammatory disease, but its regulatory roles in SLE are unclear. We aimed to comprehensively investigate the clinical value of Metrnβ in SLE. A massive elevation of circulating Metrnβ levels was observed in SLE, and patients with an active phase displayed higher Metrnβ concentrations than those with inactive phases. Additionally, we found that Metrnβ expression was positively correlated with clinical indicators of SLE. Longitudinal cytokine and chemokine profiles revealed a disturbed immune response in SLE, with high activity profiles displayed severe pathogenic inflammation, and a positive correlation of the serum Metrnβ with CXCL9, IL10, IL18 and IL1RA was observed as well. Moreover, Metrnβ expressions exhibited an inverse correlation with Treg and B10. Of note, a significant decrease of ILC2 was found in SLE, and there was a negative correlation of Metrnβ with ILC2 as well. Further ROC analysis showed that the area under the curve (AUC) for Metrnβ was 0.8250 (95% CI: 0.7379–0.9121), with a cutoff value of 1131 pg/mL to effectively distinguish SLE patients from healthy controls. Our study herein demonstrated for the first time that Metrnβ values were increased and were immunologically correlated with SLE activity, which could be utilized as an alternative biomarker for the early identification and predicting of the immuno-response of SLE.

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Section: Discussionmentioning

confidence: 99%

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus

Zhang,

Cai,

et al. 2023

IJMS

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Long-term depot specific changes in adipose tissue after treatment of acromegaly

Falch,

Godang,

Lekva

et al. 2024

European Journal of Endocrinology

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Context Patients with active acromegaly present a decreased adipose tissue (AT) mass, and short-term studies show that treatment leads to AT depot specific gain. However, it remains unclear if the increase is persistent in the long-term perspective and/or is sex dependent. Design To characterize the depot specific changes of AT after treatment of acromegaly and identify contributing factors. Methods Adipose tissue, including visceral (VAT), subcutaneous (SAT), total (TAT) and android to gynoid ratio (A/G ratio) were measured by Dual Energy X-ray Absorptiometry (DXA) at diagnosis (n=62), and after treatment at short-term (median (IQR) 1.9 (1.5-2.3)) and long-term 5.5 (3.9-9.5) years, and correlated to clinical and biochemical measurements. Growth hormone (GH), insulin-like growth factor I (IGF-1), glucose and HbA1c levels, gonadal status, and the presence of diabetes mellitus were recorded. Remission status was assessed at the long-term visit (IGF-1/ULN≤1.3). Differences in the temporal course of AT from baseline to short- and long-term follow-up according to sex, diabetes, gonadal and remission status were evaluated by mixed model analysis, adjusted for age. Results Despite a stable body mass index, VAT and A/G ratio increased at both time points, whereas SAT mainly increased at short-term, plateauing afterwards (p<0.05 for all). VAT and A/G ratio were higher in men (p=0.035 and p<0.001), and the A/G ratio increased more than in women (p=0.003). Glucose and HbA1c decreased short-term (p<0.05) and remained stable at long-term. The increase in AT depots correlated with the decrease of disease activity at long-term. Remission status had no effect on changes in AT mass during follow-up. Conclusion Treatment of acromegaly leads to an increase in AT mass in a depot and sex specific manner both at short-term and long-term follow-up. Glucose metabolism improves rapidly after disease control and persists.

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Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly

Cited by 2 publications

References 53 publications

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus

Long-term depot specific changes in adipose tissue after treatment of acromegaly

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