Gene expression profiling of <i>p53</i> and <i>c-myc</i> in HTLV-1 positive blood donors in Congo
Patrina Joseph Iloukou,
Anicet L.M. Boumba,
Freddy S. Pouki
et al.
Abstract:Objectives. The HTLV-1 infection persists for life, remaining as asymptomatic viral reservoirs in most patients, ensuring the chain of transmission, but around 4% develop adult T-cell leukemia/lymphoma (ATLL). HTLV-1 is an oncogenic retrovirus that transforms CD4+ T lymphocytes and deregulates the lymphoproliferative pathways that contribute to the development of ATLL. To achieve cell transformation, most oncogenic retroviruses use proto-oncogene capture transduction, with proviral integration disrupting the e… Show more
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