Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome

Ju, Youlun; Zheng, Jiangjun; Deng, Fengyuan; Zhao, Wenjie; Yan, Chen; Huang, Qiaoniang; Huang, Renliang; Wen, Lianggong; Yue, Xiaoyang; Petersen, Frank; Yu, Xinhua

doi:10.3389/fimmu.2018.02362

Cited by 9 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the four mouse strains, the C3H/He and BALB/c strains were susceptible but the DBA/1J and C57BL/6J strains were resistant to the Ro60_316-335 peptide-induced SS-like disease (131). Notably, ectopic expression of MHC II molecules on the glandular epithelial surface, a feature of human SS, has been observed in this model as a pre-symptomatic event, and the ectopic expression of MHC II molecules is mediated by the adjuvant (132). In addition, depletion of B cells with an anti-CD20 monoclonal antibody could prevent mice from developing SS-like disease, suggesting an essential role of B cells in disease pathogenesis (130).…”

Section: Ro60 Peptide-induced Mouse Modelmentioning

confidence: 83%

“…In addition to that in genetic mouse models, ectopic expression of MHC II molecules on glandular epithelial cells has been observed in two induced mouse models: the M3R immunization-induced model (126) and the Ro60_316-335 peptide-induced mouse model (132). Interestingly, in the Ro60_316-335 peptide-induced model, ectopic expression of MHC II molecules is caused by the adjuvant and is an early pre-symptomatic event during the development of disease (132), suggesting that (i) ectopic expression of MHC II molecules can also be caused by environmental factors and (ii) ectopic expression of MHC II molecules might be involved in the development of disease.…”

Section: Ectopic Expression Of Mhc II Moleculesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Mouse Models of Sjögren's Syndrome

et al. 2020

Self Cite

View full text Add to dashboard Cite

Sjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression of MHC II molecules on glandular epithelial cells. In contrast to the well-characterized clinical and immunological features, the etiology and pathogenesis of SS remain largely unknown. Animal models are powerful research tools for elucidating the pathogenesis of human diseases. To date, many mouse models of SS, including induced models, in which disease is induced in mice, and genetic models, in which mice spontaneously develop SS-like disease, have been established. These mouse models have provided new insight into the pathogenesis of SS. In this review, we aim to provide a comprehensive overview of recent advances in the field of experimental SS.

show abstract

Section: Ro60 Peptide-induced Mouse Modelmentioning

confidence: 83%

Section: Ectopic Expression Of Mhc II Moleculesmentioning

confidence: 99%

Recent Advances in Mouse Models of Sjögren's Syndrome

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Again, the observed phenotype was strain dependent (145). Interestingly, these mice showed ectopic MHCII expression in their LGs even before disease presentation (146). The generation of anti-La autoantibodies in both models, suggests intermolecular epitope spreading.…”

Section: M3r (M3 Muscarinic Acetylcholine Receptor) Peptide Immunisationmentioning

confidence: 86%

Experimental models of Sjögren's syndrome: differences and similarities with human disease

Kaklamanos

Goules

Tzioufas

2022

Clinical and Experimental Rheumatology

View full text Add to dashboard Cite

Mouse models have been employedextensively to provide pathogenetic insights into many complex human disorders including systemic autoimmune diseases. The explosion of biotechnology and molecular biology have simplified the procedures to design and generate mouse models with the phenotype of interest. In this line, more than 30 mouse models have been proposed or developed to resemble Sjögren's syndrome (SS) in humans, in an attempt to better understand the pathophysiology of the disease and design more effective treatments. So far, none of these models has been proven an ideal recapitulation of the human disease, although each model mimics particular aspects of the human SS counterpart. This review summarises the main characteristics of the mouse models of SS that have been developed hitherto, comparing them with the human SS in terms of clinical features, sex predilection, histopathology, autoantibodies production, and propensity for lymphoma. The interpretation of these experimental models with cautiousness and the realisation of the differences between human and mouse physiology and disease pathophysiology, may render mice a useful tool to study in depth SS and reveal new therapeutic perspectives.

show abstract

“…Previous GO analysis showed that DEGs were mainly enriched in antigen presentation/processing, protein transport, immune/defense response and protein localization. [ 52 , 53 ] In this study, we expanded the sample size for GO analysis based on previous research. [ 54 ] The results indicated that in addition to enrichment in the above pathways, DEGs were significantly enriched in T cell activation, immune cell proliferation and cytoplasm endocytic vesicle, especially in T cell activation and cytoplasmic vesicle transport.…”

Section: Discussionmentioning

confidence: 99%

Uncovering potential new biomarkers and immune infiltration characteristics in primary Sjögren’s syndrome by integrated bioinformatics analysis

Zhang,

Ji,

Bao

et al. 2023

Medicine

View full text Add to dashboard Cite

Primary Sjögren’s syndrome (pSS) is known as autoimmune disease characterized by damage to endocrine glands, such as the salivary and lacrimal glands. This study aimed to identify potential biomarkers for pSS using integrated bioinformatics analysis and explore the relationship between differentially expressed genes (DEGs) and immune infiltration. Three pSS datasets (GSE7451, GSE23117, and GSE40611) from the gene expression omnibus database were integrated. All the datasets were processed in R (version 4.0.3). A total of 16 immune cells and 13 immune functions were obtained. The top immune cell and immune function were “activated” dendritic cells and major histocompatibility complex class I. Correlation analysis showed the top correlation among 16 immune cells were B cells and tumor infiltrating lymphocytes, check-point and T cell co-stimulation, respectively. In comparisons of immune score, “activated” dendritic cells (.657 vs 594, P < .001), B cells (.492 vs 434, P = .004), macrophages (.631 vs 601, P = .010), inflammation-promoting (.545 vs 478, P < .001), Type I interferon Reponse (.728 vs 625, P < .001) and so on were higher in pSS than control group. In correlation analysis, the up-regulation of interferon induced protein with tetratricopeptide repeats 1 gene was strongly correlated with Type I interferon response with a correlation coefficient of .87. The receiver operating characteristic curve of 5 genes showed that the area under curve was.891. In the verification model, the area under curve was.881. In addition, disease ontology analysis supported the association between DEGs and pSS. In summary, pSS has a variety of DEGs in immune infiltration, which is worthy of the attention from clinicians.

show abstract

Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome

Cited by 9 publications

References 24 publications

Recent Advances in Mouse Models of Sjögren's Syndrome

Recent Advances in Mouse Models of Sjögren's Syndrome

Experimental models of Sjögren's syndrome: differences and similarities with human disease

Uncovering potential new biomarkers and immune infiltration characteristics in primary Sjögren’s syndrome by integrated bioinformatics analysis

Contact Info

Product

Resources

About