Gene expression profiling in multiple sclerosis: A disease of the central nervous system, but with relapses triggered in the periphery?

Brynedal, Boel; Khademi, Mohsen; Wallström, Erik; Hillert, Jan; Olsson, Tomas; Duvefelt, Kristina

doi:10.1016/j.nbd.2009.11.014

Cited by 54 publications

(58 citation statements)

References 45 publications

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“…Importantly, the decreased expression of HGF in CSF cells from MS patients conformed to the data from a comparable transcriptomic analysis (Supplementary Fig. 1 (Brynedal et al, 2010)). Our control CSF samples were obtained from patients with sarcoidosis, HTLV 1 myelopathy, movement disorder, cerebral vascular disease, lymphoma and ischemic myelopathy.…”

Section: Decreased Csf Expression and Protein Levels Of Hgf In Ms Patsupporting

confidence: 80%

Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis

Müller

Jun

Conlon

et al. 2012

Journal of Neuroimmunology

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Section: Decreased Csf Expression and Protein Levels Of Hgf In Ms Patsupporting

confidence: 80%

Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis

Müller

Jun

Conlon

et al. 2012

Journal of Neuroimmunology

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“…S, stable; R, relapse; I, interferon; G, glatiramer; N, no treatment; m, male; f, female. and 14 patients in relapse (15). The poor agreement of our study and previous work is likely due to differences in microarrays, differences in the cell types used as the source of mRNA, the use of paired rather than unpaired samples, the limited results reported from some studies, and small sample sizes leading to false positive results.…”

Section: R E S E a R C H A R T I C L E M O L M Econtrasting

confidence: 62%

Gene Expression Changes in Multiple Sclerosis Relapse Suggest Activation of T and Non-T Cells

Lindsey

Agarwal

Tan

2010

Mol Med

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A defining feature of multiple sclerosis (MS) is the occurrence of clinical relapses separated by periods of clinical stability. Better understanding of the events underlying clinical relapse might suggest new approaches to treatment. The objective of this study was to measure changes in the expression of RNA in the blood during relapse. We used microarrays to measure mRNA expression in paired samples from 14 MS patients during clinical relapse and while stable. Seventy-one transcripts changed expression at the P < 0.001 significance level. The most notable finding was decreased expression of transcripts with regulatory function, expressed primarily in non-T cells. These decreased transcripts included the interleukin-1 receptor antagonist, which had a corresponding decrease in the protein concentration in serum. Transcripts with increased expression were expressed primarily in T cells. Pathways analysis suggested involvement of the cytokine network, coagulation and complement cascades, IL-10 signaling and NF-κB signaling. We conclude that there are alterations of mRNA expression in both T cells and non-T cells during MS relapse.

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“…10 We investigated the expression of these genes and found that they were differently expressed in our study as well ( Table 1).…”

Section: Dna Microarray Analysismentioning

confidence: 65%

MS risk genes are transcriptionally regulated in CSF leukocytes at relapse

et al. 2012

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Gene expression profiling in multiple sclerosis: A disease of the central nervous system, but with relapses triggered in the periphery?

Cited by 54 publications

References 45 publications

Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis

Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis

Gene Expression Changes in Multiple Sclerosis Relapse Suggest Activation of T and Non-T Cells

MS risk genes are transcriptionally regulated in CSF leukocytes at relapse

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