Gene Expression Profiling For Diagnosis of Multiple Primary Malignant Tumors

Abstract

Background: The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and the increased aging of the population. For patients with a prior cancer history, distinguishing tumor recurrence or metastasis from a second malignant tumor has important prognostic and therapeutic implications and still represents a difficult problem in clinical practice. Methods: In this study, we evaluated the performance of a 90-gene expression assay and explored its potential diagnostic utility for MPMTs across a broad spectrum of tumor types. Twenty-four MPMT patients from Sir Run Run Shaw Hospital, college of medicine, Zhejiang University were enrolled in this study. A total of 51 MPMT specimens met all quality control criteria and were analyzed by the 90-gene expression assay. Results: For each clinical specimen, the tumor type predicted by the 90-gene expression assay was compared with its reference diagnosis with an overall accuracy of 94.1% (48 of 51, 95% confidence interval: 0.83-0.98). Additionally, the hierarchical clustering of 90-gene expression profiling in 51 specimens revealed MPMT samples were grouped together depending on tumor types or system types rather than individual MPMT patients. Conclusions: Therefore, the 90-gene expression assay provides flexibility and accuracy in identifying the tissue origin of MPMTs, especially in squamous cell carcinoma. Future incorporation of the 90-gene expression assay in the pathological diagnosis will assist oncologists in applying precise treatments, leading to improved care and outcomes for MPMT patients.

Levels of Certain Hormones and Receptors in Tumor and Peritumoral Area in Balb/C Nude Female Mice With Multiple Primary Malignant Process Developing on the Background of Primary Immunodeficiency

“…ПМЗО могут быть вызваны различными внутренними, внешними, генетическими и терапевтическими факторами, также ключевую роль может играть общая этиология злокачественных образований [3]. Для пациентов с предшествующим раком в анамнезе определение опухолевого происхождения второго злокачественного поражения имеет большое прогностическое и терапевтическое значение и по-прежнему представляет собой сложную научную и клиническую проблему [4]. В целом у пациентов с синхронными опухолями выживаемость меньше, чем у пациентов с метахронными опухолями [5].…”