“…Genomic instability of these identified genes, involving estrogen and progesterone receptors were suspected to be associated with an increased risk of leiomyoma development, however the evidence has been inconsistent in a large scale of cases [9][10][11]. Chegini et al and Boryana et al have afforded further insights into the molecular mechanisms of leiomyoma initiation and development by highthroughput sequencing technology [12,13], demonstrating that Background/aims: Uterine leiomyoma is the ahead benign tumor of the female genital tract, which resulted in menstrual abnormalities, recurrent pregnancy loss, and other serious gynecological disorders in women. Recently, as the process of exploring the brief molecular mechanisms of tumorgenesis, microRNAs (miRNAs) have attracted much more attention.…”