Gene expression profile of immune-check point in response to Trastuzumab therapy in patients with HER-2 positive breast cancer
Noor A. Abdullah,
Naael Hussein Ali,
Nabeel Abdu Aljaleel
Abstract:Aim: To clarify the association between response to Trastuzumab and molecular expression of TIM-3 and FOXP-3 immune checkpoints.
Materials and Methods: FOXP-3 and TIM-3 expression in peripheral blood was analyzed using qPCR, and the serum level of Trastuzumab was estimated using an immune sorbent enzyme assay.
Results: During treatment with Trastuzumab, the FOXP-3 gene expression showed a significant decline throughout one year of treatment, going from 0.85 at cycle 9 to 0.75 at cycle 17. While the TIM-3 gene … Show more
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