Gene Expression of Mutant Erythropoietin in Hepatocellular Carcinoma

Funakoshi, Akihiro; Muta, H.; Baba, Tadashi; Shimizu, Shun

doi:10.1006/bbrc.1993.2104

Cited by 12 publications

(7 citation statements)

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“…Wehave reported the nucleotide sequence of CDNA in tumor tissue in 1993, and showed mutant EPOmRNAexpressions which produce bioactive mutant EPOprotein in hepatocellular carcinoma tissue (4). There were three differences from those in the reported sequences of normal EPOCDNA (4,5); however, the substitutions of the aminoacids had no effect on biological activity. In our case, the nucleotide sequences of CDNA in tumor tissue were normal.…”

Section: Discussioncontrasting

confidence: 62%

“…Here, in a case of renal cell carcinoma with erythrocytosis, we demonstrate the increased expression of EPOmRNA in the tumor tissue by reverse transcriptase-polymerase chain reaction (RT-PCR) and Northern blot analysis, and detect the EPO protein by immunostaining. Previously, we have reported the mutant EPOCDNAin hepatocellular carcinoma tissue (4). In this study, we also analyzed the nucleotide sequences of the EPOCDNAin normal and tumor tissues.…”

Section: Introductionmentioning

confidence: 99%

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Gene Expression of Erythropoietin in Renal Cell Carcinoma.

et al. 1999

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A 57-year-old man with renal cell carcinoma and erythrocytosis showed a high serum level of erythropoietin (EPO). High EPOsignal was observed on Northern blot analysis and RT-PCR in the total RNAextracted from the renal tumor. Immunohistochemical staining also demonstrated tumor tissue with high immunostaining of EPO. Nucleotide sequences of EPOCDNA in the tumor were normal. To date, only one report has discussed the nucleotide sequences of a tumor's EPO gene; it showed mutant EPO CDNAin hepatocellular carcinoma tissue. This is the first demonstration of normal EPO CDNAin renal cell carcinoma. (Internal Medicine 38: 991-994, 1999)

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Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Gene Expression of Erythropoietin in Renal Cell Carcinoma.

et al. 1999

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“…While specific EPO question arises whether this also occurs in RCCs. And binding to the cell surface EPO-R occurs with somewhat finally, pathologically elaborated EPO in RCCs may conlower affinities in both the malignant and the primary ceivably be mutated, as was shown in hepatoma cells HCT cell lines than in erythroid progenitor or mouse [62], which may also cause changes in ligand-binding proximal tubular cells (K d ϳ 1.1 to 1.6 nmol/L vs. ϳ 96 kinetics and thus alter postreceptor events. pmol/L, respectively) [1], maximal ligand binding, B max , Anagnostou et al demonstrated previously that EPO in malignant and normal human cells is greater.…”

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confidence: 99%

Erythropoietin stimulates proliferation of human renal carcinoma cells

Westenfelder

Baranowski

2000

Kidney International

207

138

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“…Erythrocytosis is one of the more common paraneoplastic syndromes in HCC, but the pathogenesis of the phenomenon remains obscure. It has been speculated that tumors produce erythropoietin (Epo), and several studies on Epo in tumor tissues have been reported [2,3]. We report a case of Epo-producing HCC associated with erythrocytosis.…”

Section: Introductionmentioning

confidence: 90%

Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma

et al. 2000

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A case of erythrocytosis caused by a hepatocellular carcinoma (HCC) that produced erythropoietin (Epo) is described. A 64-year-old man, with a huge HCC tumor in the right lobe of the liver, showed a high concentration of hemoglobin and increased levels of serum Epo, alpha-fetoprotein (AFP), and protein induced by vitamin K absence II (PIVKA-II). Right lobectomy of the liver was performed. Histological findings of the specimen showed a moderately differentiated HCC. The existence of Epo was confirmed immunohistochemically only in the tumor tissue and not in the normal liver tissue. Erythrocytosis disappeared and the serum levels of Epo, AFP, and PIVKA-II returned to the normal range after the operation. Within 2 months after the operation, recurrent tumors appeared in the remnant liver, and the patient died 13 months after the operation.

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Gene Expression of Mutant Erythropoietin in Hepatocellular Carcinoma

Cited by 12 publications

References 0 publications

Gene Expression of Erythropoietin in Renal Cell Carcinoma.

Gene Expression of Erythropoietin in Renal Cell Carcinoma.

Erythropoietin stimulates proliferation of human renal carcinoma cells

Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma

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