Gene expression of IL-10 in relationship to TNF-α, IL-1β and IL-2 in the rat brain following middle cerebral artery occlusion

Zhai, Qihui; Futrell, Nancy; Chen, Fangjie

doi:10.1016/s0022-510x(97)00154-8

Cited by 118 publications

(62 citation statements)

References 43 publications

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“…Recent animal experiments demonstrated that MSCs transplantation alone improved neurological deficits in cerebral infarction. TNF- is a pro-inflammatory cytokine, also expressed in brain tissue following cerebral ischemia (24,25). It is one of many specific molecules thought to trigger neuron death in the penumbra after a stroke.…”

Section: Discussionmentioning

confidence: 99%

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

et al. 2009

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“…Impairment of the balance of pro-and anti-inflammatory cytokines may lead to disease progression and a more severe outcome after cerebral ischemia. It has been reported that the expressions of both pro-and anti-inflammatory cytokines are induced rapidly by focal or global brain ischemia (3,16,17). Over expression of IL-1β or TNF-α, the two major pro-inflammatory cytokines, exacerbates the brain infarction after cerebral ischemia, whereas their inhibition has been reported to attenuate the infarct volume (18 -20).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Guizhi-Fuling-Capsules on Rat Brain Ischemia/Reperfusion Injury

Qiu

Mao³

et al. 2007

J Pharmacol Sci

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Abstract. Previous studies revealed that Guizhi-Fuling-Capsules (GZFLC), a traditional Chinese medical (Kampo) formulation composed of five kinds of medicinal plants, Cinnamomum cassia BLUME (Cinnamomi Cortex), Paeonia lactiflora PALL. (Peonies Radix), Paeonia suffruticosa ANDREWS (Moutan Cortex), Prunus persica BATSCH (Persicae Semen), and Poria cocos WOLF (Hoelen), exerts a protective effect against vascular injury and has a protective effect against glutamate-or nitro oxide-mediated neuronal damage. In the present study, the effect of GZFLC in a rat in vivo model of focal cerebral ischemia and reperfusion was investigated. Administration of GZFLC (0.3 and 0.9 g / kg, p.o.) after focal cerebral ischemia significantly decreased brain infarction and water contents in rats subjected to 2-h ischemia followed by 24-h reperfusion from 31.72 ± 2.49%, 84.76 ± 1.63% in the model group to 17.31 ± 3.66%, 82.51 ± 1.36% and 8.30 ± 3.73%, 81.35 ± 1.73%, respectively. Furthermore, analysis of inflammatory cytokines in ischemic brain showed that GZFLC treatment significantly down-regulated expressions of pro-inflammatory cytokines including interleukin (IL)-1β and tissue necrosis factor-α and markedly up-regulated expressions of anti-inflammatory cytokines IL-10 and IL-10R both in mRNA and protein levels. The serum levels of these inflammatory cytokines were also regulated the same way. These results suggested that GZFLC may be beneficial for the treatment of brain ischemia-reperfusion injury partly due to its anti-inflammatory properties.

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“…Experimentally, kidneys and hearts transplanted from BD animals show accelerated acute rejection in comparison to grafts from living donors (2). This is thought to be triggered by an increased release of proinflammatory cytokines (2,5,31), an up-regulation of major histocompatibility complex (MHC/HLA class I and II) antigens and co-stimulating B7 in peripheral organs (5,32).…”

Section: Discussionmentioning

confidence: 99%

Brain Death Impairs Pancreatic Microcirculation

Obermaier

Dobschuetz

Keck

et al. 2004

American Journal of Transplantation

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Brain death (BD) influences the quality of donor grafts in transplantation. To evaluate the impact of BD on pancreas grafts, we investigated the influence of BD on the microcirculation and histology of the pancreas in a rat model of explosive BD. A group of Wistar rats (n = = 7), rendered brain dead by inflating an intracranially inserted Fogarty catheter was compared with controls (CO) using intravital epifluorescence-microscopy over 4 h after BD induction; functional capillary density (FCD), leukocyte adherence (AL) in post-capillary venules, histology and pancreatic enzymes were investigated. Four hours after BD, FCD decreased (333 ± 11 vs. baseline 444 cm/cm 2 ± 5 SEM; p < 0.01) and showed lower values than CO (388 ± 9 p < 0.01). In BD, AL was increased (628 cells/mm 2 ± 110 SEM vs. baseline 123 ± 32, and vs. CO 180 ± 33; p < 0.001). BD caused increased histological damage (CO 1.6 scorepoints ± 0.7 SD vs. BD 8.3 ± 7.1; p < 0.05). Amylase was higher in BD (p < 0.05) but did not reach pathological values. We show for the first time that BD causes relevant changes in pancreatic microcirculation, histology and leukocyte endothelial interaction which might have a serious impact on the function of grafts. New strategies for preventing this damage are therefore highly desirable in order to improve the outcome of pancreas transplantation.

show abstract

Gene expression of IL-10 in relationship to TNF-α, IL-1β and IL-2 in the rat brain following middle cerebral artery occlusion

Cited by 118 publications

References 43 publications

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

Protective Effects of Guizhi-Fuling-Capsules on Rat Brain Ischemia/Reperfusion Injury

Brain Death Impairs Pancreatic Microcirculation

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