Gene expression of circulating tumour cells and its correlation with tumour stage in breast cancer patients

Bölke, Edwin; Orth, Klaus; Gerber, Peter Arne; Lammering, Guido; Mota, Rodrigo; Peiper, Matthias; Matuschek, Christiane; Budach, Wilfried; Rusnak, E; Shaikh, S; Dogan, Basak E.; Prisack, H.; Bojar, Hans

doi:10.1186/2047-783x-14-8-359

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…The immunocytochemical detection of FPTCs turned out to be an independent additional strong prognostic factor as also described in other tumor entities before [ 22 - 24 ]. The short survival time of these patients is similar to patients with an M1-disease [ 25 , 26 ].…”

Section: Discussionsupporting

confidence: 59%

Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment

et al. 2011

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ObjectiveTreatment options for patients with diffuse type gastric cancer (linitis plastica) are discussed controversial. It is sometimes discussed that these patients should be treated primarily in palliative intention conservative without resection.MethodsIn a single-center analysis, we investigated 120 patients with diffuse type gastric cancer. All patients underwent a total gastrectomy, 45 patients even a multivisceral resection because of infiltrating growth, or metastases. Serum tumor marker CEA, CA 72-4, and CA 19-9 were recorded in all patients before surgery. An immunocytochemical detection of free peritoneal tumor cells (FPTC) using Ber-EP4 antibody was correlated with tumor stage and survival. Median follow-up time was 38 months.ResultsComplete resection rate was 31% (n = 37). 61% (n = 73) of all patients had already distant metastases at the time of surgery, 80% of them peritoneal carcinomatosis. Median survival for the whole group was 8 months, after complete resection 17 months. Lavage cytology, distant metastases, resection rate, and CA19-9 levels had significant influence on survival.ConclusionA significant survival advantage for patients with diffuse type gastric cancer can only be achived after complete resection. We could define a subset of patients with an extremely poor prognosis even after surgical resection. Meticulous preoperative staging, including a diagnostic laparoscopy to exclude peritoneal carcinomatosis and free peritoneal tumor cells before resection should be mandatory in these patients.

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Section: Discussionsupporting

confidence: 59%

Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment

et al. 2011

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“…23 Moreover, it was accompanied by elevation of CTCs in cases of lung cancer, breast cancer, urothelial carcinoma and gastric cancer. [24][25][26][27][28] Since 2004, a number of CTCs has been approved by the FDA to evaluate the ecological prognosis and outcome. In the current study, it was shown that the higher the number of CTCs in the serum, the worse the prognosis for the patient.…”

Section: Discussionmentioning

confidence: 99%

Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Pan¹,

Hao²,

Sun³

et al. 2021

CMAR

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Background: Circulating tumor cells (CTCs) are cells that have been shed into the vasculature from a primary tumor and circulate in the bloodstream. It has been suggested that detecting CTCs could help the clinician to detect early metastasis or recurrence more effectively. This trial sets out to assess the detection and clinical value of CTCs as an assisted prognostic marker in patients with colon cancer and rectal cancer. Methods: A prospective cohort of patients with colorectal cancer (CRC) was enrolled from July 2015 to February 2018 in

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“…This characterization could give hints towards cancer prognosis. For example, Bölke et al described in 2009 [ 57 ], that the expression of certain genes is related to advanced breast cancer stages. Additionally, a characterization of CTCs could help to personalize treatment by increasing efficiency and reducing side effects, resulting in a better outcome and an increased survival, rendering great benefit to the patients.…”

Section: Conclusion and Future Prospectivementioning

confidence: 99%

Detection of Circulating Tumour Cells from Blood of Breast Cancer Patients via RT-qPCR

Andergassen

Kölbl

Hutter

et al. 2013

Cancers

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Breast cancer is still the most frequent cause of cancer-related death in women worldwide. Often death is not caused only by the primary tumour itself, but also by metastatic lesions. Today it is largely accepted, that these remote metastases arise out of cells, which detach from the primary tumour, enter circulation, settle down at secondary sites in the body and are called Circulating Tumour Cells (CTCs). The occurrence of such minimal residual diseases in the blood of breast cancer patients is mostly linked to a worse prognosis for therapy outcome and overall survival. Due to their very low frequency, the detection of CTCs is, still a technical challenge. RT-qPCR as a highly sensitive method could be an approach for CTC-detection from peripheral blood of breast cancer patients. This assumption is based on the fact that CTCs are of epithelial origin and therefore express a different gene panel than surrounding blood cells. For the technical approach it is necessary to identify appropriate marker genes and to correlate their gene expression levels to the number of tumour cells within a sample in an in vitro approach. After that, samples from adjuvant and metastatic patients can be analysed. This approach may lead to new concepts in diagnosis and treatment.

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Gene expression of circulating tumour cells and its correlation with tumour stage in breast cancer patients

Cited by 10 publications

References 17 publications

Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment

Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment

Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Detection of Circulating Tumour Cells from Blood of Breast Cancer Patients via RT-qPCR

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