Gene expression in stress urinary incontinence: a systematic review

Isali, Ilaha; Mahran, Amr; Khalifa, Ahmad; Sheyn, David; Neudecker, Mandy; Qureshi, Arshna; Conroy, Britt; Schumacher, Fredrick R.; Hijaz, Adonis; El-Nashar, Sherif A.

doi:10.1007/s00192-019-04025-5

Cited by 19 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings of the current systematic review are in line with and expand the knowledge of previously published reviews [ 17 , 129 , 130 , 131 , 132 ]. The systematic review on gene expression differences of Isali et al, included studies until September 2017.…”

Section: Discussionsupporting

confidence: 89%

“…In women, SUI often coexists with pelvic organ prolapse (POP), and both are due to lack of support of connective tissues [ 15 , 16 ]. A systematic review of Isali et al [ 17 ] on gene expression differences in SUI that was conducted through September 2017 described 13 genes that were differentially expressed in SUI patients. Those genes are involved in intermediate filament cytoskeleton and extracellular matrix organization.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies

Post

Widomska

Grens

et al. 2022

IJMS

View full text Add to dashboard Cite

Stress urinary incontinence (SUI) is a common and burdensome condition. Because of the large knowledge gap around the molecular processes involved in its pathophysiology, the aim of this review was to provide a systematic overview of genetic variants, gene and protein expression changes related to SUI in human and animal studies. On 5 January 2021, a systematic search was performed in Pubmed, Embase, Web of Science, and the Cochrane library. The screening process and quality assessment were performed in duplicate, using predefined inclusion criteria and different quality assessment tools for human and animal studies respectively. The extracted data were grouped in themes per outcome measure, according to their functions in cellular processes, and synthesized in a narrative review. Finally, 107 studies were included, of which 35 used animal models (rats and mice). Resulting from the most examined processes, the evidence suggests that SUI is associated with altered extracellular matrix metabolism, estrogen receptors, oxidative stress, apoptosis, inflammation, neurodegenerative processes, and muscle cell differentiation and contractility. Due to heterogeneity in the studies (e.g., in examined tissues), the precise contribution of the associated genes and proteins in relation to SUI pathophysiology remained unclear. Future research should focus on possible contributors to these alterations.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies

Post

Widomska

Grens

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…6 More recent GeneMANIA software analysis of gene expression profiles has confirmed the differential expression of these three proteoglycans among 13 genes involved in intermediate filament cytoskeleton and ECM organization differentially expressed in SUI patients. 28 Taken together with our findings, these data point to a disruption of proteoglycan homeostasis negatively impacting collagen and elastin fiber network integrity in the injured vaginal and urethral tissues of women suffering from SUI.…”

Section: Discussionsupporting

confidence: 85%

The extracellular matrix molecules versican and hyaluronan in urethral and vaginal tissues in stress urinary incontinence

Harten

Evanko

Choe

et al. 2021

Neurourology and Urodynamics

View full text Add to dashboard Cite

Abnormal extracellular matrix (ECM) changes are correlated with stress urinary incontinence (SUI). The ECM components versican (Vcan) and hyaluronan (HA) play key roles in regulating tissue inflammation and maintaining connective tissue homeostasis. We analyzed the localization and expression of these ECM components in urethral and vaginal tissues from a rat model of urinary incontinence and from human clinical specimens. Methods: Nulliparous rats underwent vaginal distension (VD), a rodent model of SUI, or a sham procedure. Tissues were harvested from six rats per group at days 1, 4, and 21 for immunohistochemistry and RNA expression analysis of ECM components. Periurethral vaginal samples from female patients with SUI were also examined. Results: High-intensity staining for Vcan was observed 1 day after procedure in both control and VD animals. This level of abundance persisted at day 4 in VD compared to control, with concurrent reduced messenger RNA (mRNA) expression of the Vcan-degrading enzymes ADAMTS5 and ADAMTS9 and reduced staining for the Vcan cleavage epitope DPEAAE. Abundance of HA was not different between VD and control, however mRNA expression of the HA synthase Has2 was significantly reduced in VD tissues at day 4. Abundant Vcan staining was observed in 60% of SUI patient samples, which was strongest in regions of disrupted elastin. Conclusion: Reduction of Vcan-degrading enzymes and HA synthases at day 4 postsurgery indicates a potential delay in ECM turnover associated with SUI. Abundant Vcan is associated with inflammation and elastin fiber network disruption, warranting further investigation to determine its role in SUI pathogenesis.

show abstract

“…Goins et al [ 39 ] reported that nerve growth factor gene delivery to sensory ganglia cells innervating the bladder using herpes simplex virus decreased the PVR in rats with neurogenic DU. Several studies investigating the genetic factors of SUI and developing future targeted therapies for SUI have reported the role of genes such as growth factor receptor-bound protein 2 [ 40 ]. Future research on gene therapy may be applicable to the treatment of incontinence with UAB.…”

Section: Managementmentioning

confidence: 99%

Management of Urinary Incontinence With Underactive Bladder: A Review

Cho

Kim

2020

Int Neurourol J

View full text Add to dashboard Cite

Urinary incontinence is caused by storage function failure, while underactive bladder (UAB) is caused by a decline in detrusor contractility and voiding dysfunction. As the treatment mechanisms for incontinence and UAB are contrary to each other, it is difficult to treat both incontinence and UAB, and the patient’s quality of life can be further degraded. Conventional midurethral sling (MUS), such as transobturator tape or retropubic MUS, introduces a risk of postoperative voiding dysfunction in stress urinary incontinence with UAB. However, there have been several reports about the efficacy and safety of conventional MUS. Adjustable sling procedures, such as transobturator adjustable tape or the Remeex system, have better outcomes than conventional MUS because they control tension both during and after surgery. When voiding dysfunction occurs after incontinence treatment with UAB, voiding symptoms can be improved by various therapeutic modalities. Clean intermittent catheterization is recommended for patients with significant increased postvoid residual volumes or urinary retention. Although pharmacotherapy such as with alpha-blockers or parasympathomimetics can be considered for UAB, there is insufficient evidence of their effect on incontinence with UAB. Future therapies, such as stem cell therapy or gene therapy, may be used to treat incontinence with UAB. The possibility of management urgency urinary incontinence that related to detrusor hyperactivity with impaired contractility using sacral neuromodulation has been suggested. Further research is needed to establish evidence for the efficacy and safety of treatments for incontinence with UAB and improve patient quality of life.

show abstract

Gene expression in stress urinary incontinence: a systematic review

Cited by 19 publications

References 55 publications

Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies

Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies

The extracellular matrix molecules versican and hyaluronan in urethral and vaginal tissues in stress urinary incontinence

Management of Urinary Incontinence With Underactive Bladder: A Review

Contact Info

Product

Resources

About