Gene expression in pre-implantation mammalian embryos

Schultz, Gilbert A.; Heyner, Susan

doi:10.1016/0165-1110(92)90029-9

Cited by 77 publications

(48 citation statements)

References 119 publications

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“…This is not surprising when considering that the oocyte provides factors to the embryo that orchestrate the early events of embryogenesis (Schultz & Heyner 1992, Minami et al 2007, remodel the genome (Torres-Padilla et al 2006) and repair DNA damage in both male and female nuclei (Genesca et al 1992). Unfortunately, the occurrence of post-ovulatory ageing is not uncommon.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and ageing of the post-ovulatory oocyte

2013

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With extended periods of time following ovulation, the metaphase II stage oocyte experiences deterioration in quality referred to as post-ovulatory oocyte ageing. Post-ovulatory ageing occurs both in vivo and in vitro and has been associated with reduced fertilization rates, poor embryo quality, post-implantation errors and abnormalities in the offspring. Although the physiological consequences of post-ovulatory oocyte ageing have largely been established, the molecular mechanisms controlling this process are not well defined. This review analyses the relationships between biochemical changes exhibited by the ageing oocyte and the symptoms associated with the ageing phenotype. We also discuss molecular events that are potentially involved in orchestrating post-ovulatory ageing with a particular focus on the role of oxidative stress. We propose that oxidative stress may act as the initiator for a cascade of events that create the aged oocyte phenotype. Specifically, oxidative stress has the capacity to cause a decline in levels of critical cell cycle factors such as maturation-promoting factor, impair calcium homoeostasis, induce mitochondrial dysfunction and directly damage multiple intracellular components of the oocyte such as lipids, proteins and DNA. Finally, this review addresses current strategies for delaying post-ovulatory oocyte ageing with a particular focus on the potential use of compounds such as caffeine or selected antioxidants in the development of more refined media for the preservation of oocyte integrity during IVF procedures.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and ageing of the post-ovulatory oocyte

2013

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“…TEF1 is a highly conserved transcription factor in mammals and the prototype of the gene family consisting of three or four proteins that share the same TEA DNA binding domain (43,44). 4 Recent studies using in situ hybridization and injection of a TEF1-dependent synthetic promoter suggest that the TEF1 gene family is not expressed until ZGA. 4 Since TEF1 itself is not required for preimplantation development (46), another member of this family may activate enhancers in preimplantation embryos.…”

Section: Acquisition Of Enhancer Functionmentioning

confidence: 99%

“…4 Recent studies using in situ hybridization and injection of a TEF1-dependent synthetic promoter suggest that the TEF1 gene family is not expressed until ZGA. 4 Since TEF1 itself is not required for preimplantation development (46), another member of this family may activate enhancers in preimplantation embryos.…”

Section: Acquisition Of Enhancer Functionmentioning

confidence: 99%

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Regulation of Gene Expression at the Beginning of Mammalian Development

Nothias

Majumder

Kaneko

et al. 1995

Journal of Biological Chemistry

278

187

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“…The initial stages of embryo development are sustained by maternally provided transcripts and proteins accumulated in the oocyte during oogenesis (Schultz & Heyner 1992, Minami et al 2007, Tang et al 2007. These factors are crucial for early developmental events in embryos, including axis formation, cell fate determination, and activation of the embryonic genome.…”

Section: Maternal Age and Fertilitymentioning

confidence: 99%

Ceramide and mitochondrial function in aging oocytes: joggling a new hypothesis and old players

Kujjo¹,

Perez²

2012

Reproduction

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Maternal aging adversely affects oocyte quality (function and developmental potential) and consequently lowers pregnancy rates while increasing spontaneous abortions. Substantial evidence, especially from egg donation studies, implicates the decreased quality of an aging oocyte as a major factor in the etiology of female infertility. Nevertheless, the cellular and molecular mechanisms responsible for the decreased oocyte quality with advanced maternal aging are not fully characterized. Herein we present information in the published literature and our own data to support the hypothesis that during aging induced decreases in mitochondrial ceramide levels and associated alterations in mitochondrial structure and function are prominent elements contributing to reduced oocyte quality. Hence, by examining the molecular determinants that underlie impairments in oocyte mitochondria, we expect to sieve to a better understanding of the mechanistic anatomy of oocyte aging.Reproduction (2012) 143 1-10

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Gene expression in pre-implantation mammalian embryos

Cited by 77 publications

References 119 publications

Oxidative stress and ageing of the post-ovulatory oocyte

Oxidative stress and ageing of the post-ovulatory oocyte

Regulation of Gene Expression at the Beginning of Mammalian Development

Ceramide and mitochondrial function in aging oocytes: joggling a new hypothesis and old players

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