Gene expression in nuclear microenvironments for biological control and cancer

Stein, Gary S.

doi:10.4161/cbt.6.11.5294

Cited by 3 publications

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“…Regulatory complexes are retained at target gene loci during mitosis and are distributed symmetrically to progeny cells at the completion of cell division providing additional dimensions to epigenetic control (Young et al, , ; Stein et al, , ; Pande et al, ; Zaidi et al, ). It has also been proposed that abnormalities in nuclear matrix organization may account for changes in gene expression patterns in cancer (Stein, ).…”

Section: Discussionmentioning

confidence: 99%

Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis

Scott¹,

Ghule

Stein

2015

Journal Cellular Physiology

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The early stages of carcinogenesis are linked to defects in the cell cycle. A series of cell cycle checkpoints are involved in this process. The G1/S checkpoint that serves to integrate the control of cell proliferation and differentiation is linked to carcinogenesis and the mitotic spindle checkpoint with the development of chromosomal instability. This paper presents the outcome of systems biology studies designed to evaluate if networks of covariate cell cycle gene transcripts exist in proliferative mammalian tissues including mice, rats and humans. The GeneNetwork website that contains numerous gene expression datasets from different species, sexes and tissues represents the foundational resource for these studies (www.genenetwork.org). In addition, WebGestalt, a gene ontology tool, facilitated the identification of expression networks of genes that co-vary with key cell cycle targets, especially Cdc20 and Plk1 (www.bioinfo.vanderbilt.edu/webgestalt). Cell cycle expression networks of such covariate mRNAs exist in multiple proliferative tissues including liver, lung, pituitary, adipose and lymphoid tissues among others but not in brain or retina that have low proliferative potential. Sixty-three covariate cell cycle gene transcripts (mRNAs) compose the average cell cycle network with p = e−13 to e−36. Cell cycle expression networks show species, sex and tissue variability and they are enriched in mRNA transcripts associated with mitosis many of which are associated with chromosomal instability.

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Section: Discussionmentioning

confidence: 99%

Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis

Scott¹,

Ghule

Stein

2015

Journal Cellular Physiology

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Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression

Yedavalli

Jeang

2011

Retrovirology

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Post-transcriptional regulation of HIV-1 gene expression is mediated by interactions between viral transcripts and viral/cellular proteins. For HIV-1, post-transcriptional nuclear control allows for the export of intron-containing RNAs which are normally retained in the nucleus. Specific signals on the viral RNAs, such as instability sequences (INS) and Rev responsive element (RRE), are binding sites for viral and cellular factors that serve to regulate RNA-export. The HIV-1 encoded viral Rev protein binds to the RRE found on unspliced and incompletely spliced viral RNAs. Binding by Rev directs the export of these RNAs from the nucleus to the cytoplasm. Previously, Rev co-factors have been found to include cellular factors such as CRM1, DDX3, PIMT and others. In this work, the nuclear matrix protein Matrin 3 is shown to bind Rev/RRE-containing viral RNA. This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs.

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Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation

Dowdy

2012

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Gene expression in nuclear microenvironments for biological control and cancer

Cited by 3 publications

References 26 publications

Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis

Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis

Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression

Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation

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