Gene Expression in a Swine Model of Right Ventricular Hypertrophy: Intercellular Adhesion Molecule, Vascular Endothelial Growth Factor and Plasminogen Activators are Upregulated during Pressure Overload

Carroll, Susan M.; Nimmo, Lana; Knoepfler, Paul S.; White, Fred N.; Bloor, Colin M.

doi:10.1006/jmcc.1995.0135

Cited by 31 publications

(15 citation statements)

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“…Moreover, its expression in the ventricles is increased in response to both physiological and pathological stimuli (16,19,20). Rapid pacing and pressure overload both increased ANF mRNA expression in the affected swine ventricle (17,18). Thus it is not surprising that gradual occlusion of the LCX coronary artery increased the levels of ANF mRNA in the LV and that there was a weak tendency for the increase in ANF expression to be greatest when exercise training and gradual LCX occlusion were combined.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological hypertrophy is characterized by reexpression of the so-called "fetal gene program", while physiological hypertrophy is associated with gene expression changes that are both similar and distinct from those observed in pathological hypertrophy. Ventricular expression of the atrial natriuretic factor gene (ANF) is markedly increased in response to a wide range of pathological insults (16)(17)(18), while exercise training often, but not always, elicits a similar ANF response (19)(20)(21). Thus, the expression of ANF in the ventricles is a reliable marker of cardiac hypertrophy; the magnitude of the increase in ANF expression often correlates with the magnitude of cardiac hypertrophy (22).…”

Section: Introductionmentioning

confidence: 99%

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Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart

et al. 2006

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Gradual occlusion (O) of the swine left circumflex coronary artery (LCX) with an ameroid occluder results in complete O within 3 weeks, collateral vessel development, and compensatory hypertrophy. The purpose of this investigation was to determine the independent and combined effects of O and exercise training (E) on gene expression in the swine heart. Adult Yucatan miniature swine were assigned to one of the following groups (n = 6-9/group): sedentary control (S), exercise-trained (E), sedentary swine subjected to LCX occlusion (SO), and exercise-trained swine with LCX occlusion (EO). Exercise consisted of progressive treadmill running conducted 5 d/wk for 16 weeks. Gene expression was studied in myocardium isolated from the collateral-dependent left ventricle free wall (LV) and the collateral-independent septum (SEP) by RNA blotting. E and O each stimulated cardiac hypertrophy independently (p < 0.001) with no interaction. O but not E increased atrial natriuretic factor expression in the LV, but not in the SEP. E decreased the expression of β-myosin heavy chain in the LV, but not in the SEP. E retarded the expression of collagen III mRNA in SEP; but not in the LV. Exercise training and coronary artery occlusion each stimulate cardiac hypertrophy independently and induce different patterns of gene expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart

et al. 2006

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“…In pigs, ANF, [CAM-1 (intraceilular adhesion molecule-1), TGFB (Tumor growth factor+) and VEGF (vascular endothelial growth factor) were ali increased in response to right ventncular pressure overload, but PDGF (platelet derived growth factor) was decreased (Carroll et al 1995 There is a shifi from VI to V3 myosin isoenzymes, and this change correlated with slower but more efficient myocardial contraction in nght heart failure. Although there bas been a recent surge in mechanistic studies concemiog RHF and the trend is encouraging, these still represents a disproportionately small…”

Section: Oxidative Stressmentioning

confidence: 97%

Myocardial oxidative stress changes during compensated right heart failure in rats

Pichardo

Palace

Farahmand

et al. 1999

Stress Adaptation, Prophylaxis and Treatment

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“…Carrol et al [10] found intense inflammatory infiltration in the myocardium of swine submitted to pulmonary banding after 7 hours of systolic overload. Areas of variable degrees of cellular necrosis in the hypertrophied myocardium [11][12][13] and a consequent late ventricular dysfunction [14] have also been demonstrated in hearts submitted to acute systolic stress, probably due to imbalance between the oxygen supply and demand ratio in the hypertrophic myocardium.…”

Section: Echocardiographic Parametersmentioning

confidence: 99%

<![CDATA[<B>Adjustable pulmonary trunk banding</B>: <B>comparison of two methods of acute subpulmonary ventricle hypertrophy</B>]]>

Assad¹,

Rodriguez²,

Abduch³

et al. 2006

Braz. j. cardiovasc. surg.

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Bandagem ajustável do tronco pulmonar: comparação de dois métodos de hipertrofia aguda do ventrículo subpulmonarAdjustable pulmonary trunk banding: comparison of two methods of acute subpulmonary ventricle hypertrophy Abstract Objective: This study compares ventricular hypertrophy induced by continuous versus intermittent systolic overload of the pulmonary ventricle (RV) of young goats.Methods: Three groups of seven goats were used (control, continuous, and intermittent). Systolic overload was maintained for 96 hours in the continuous group, while the intermittent group suffered four 12-hour periods of systolic overload, alternating with 12-hour resting periods. Echocardiographic and hemodynamic evaluations were performed every day. The animals were then killed for myocardial water content and weight evaluation.Results: Both study groups achieved significant increases in RV mass (p<0.05). However, significant increases of the septum mass were observed only in the Intermittent Group (p<0.05). A greater increase in the RV wall thickness was observed in the Intermittent Group (p<0.05). There was a significant difference in RV diastolic volume between the two groups (p= 0.01), with a greater RV dilation in the Continuous Group after 24 hours of continuous overload (p< 419ASSAD, RS ET AL -Adjustable pulmonary trunk banding: comparison of two methods of acute subpulmonary ventricle hypertrophy Braz J Cardiovasc Surg 2006; 21(4): 418-428 INTRODUCTIONThe concept of rapid preparation of the left ventricular (LV) was introduced by the group from Boston in 1989 to treat transposition of the great arteries (TGA) after the neonatal period. Retraining of the subpulmonary ventricle was obtained in a mean time of nine days and after this Jatene's operation was performed [1]. These authors achieved good preliminary results, however, they were not reproduced in other centers due to high morbimortality. One of the greatest limitations of this technical approach is related to the lack of adjustability of the pulmonary trunk (PT) banding. The degree of PT banding may be inadequate or imprecise and can cause an important acute systolic overload of the LV [2,3].Heart hypertrophy is the main adaptive response of a heart submitted to physiological or pathological overload. It is interesting to note that the acquisition of LV mass during physical conditioning of athletes who practice swimming for example, reaches a peak in about only one week of training. Then the LV mass remains relatively constant [4] In an attempt to improve the rapid hypertrophic process without causing injury to the myocardium of the subpulmonary ventricle, we tried to find an analogy between the physiological hypertrophic processes in static-type exercises and intermittent PT banding, where periods of systolic overload are alternated with periods of subpulmonary ventricle relaxation.We formed a hypothesis that the subpulmonary ventricle, submitted to the gradual and progressive systolic overload alternated with periods of relaxation, could cause a more benefici...

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Gene Expression in a Swine Model of Right Ventricular Hypertrophy: Intercellular Adhesion Molecule, Vascular Endothelial Growth Factor and Plasminogen Activators are Upregulated during Pressure Overload

Cited by 31 publications

References 0 publications

Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart

Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart

Myocardial oxidative stress changes during compensated right heart failure in rats

<![CDATA[<B>Adjustable pulmonary trunk banding</B>: <B>comparison of two methods of acute subpulmonary ventricle hypertrophy</B>]]>

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