Abstract:Major depressive disorder (MDD) is associated with structural and functional brain abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors, but the role of gene expression remains unclear. Here we investigated how cortical gene expression contributes to structural and functional brain abnormalities in MDD. We compared the gray matter volume and resting-state functional measures in a Chinese sample of 848 MDD patients and 749 healthy controls, and we then associated these case… Show more
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