2020
DOI: 10.3389/fnins.2020.00280
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Gene Expression Dynamics at the Neurovascular Unit During Early Regeneration After Cerebral Ischemia/Reperfusion Injury in Mice

Abstract: With increasing distribution of endovascular stroke therapies, transient middle cerebral artery occlusion (tMCAO) in mice now more than ever depicts a relevant patient population with recanalized M1 occlusion. In this case, the desired therapeutic effect of blood flow restauration is accompanied by breakdown of the blood-brain barrier (BBB) and secondary reperfusion injury. The aim of this study was to elucidate short and intermediate-term transcriptional patterns and the involved pathways covering the differe… Show more

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Cited by 24 publications
(31 citation statements)
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References 44 publications
(49 reference statements)
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“…RNAseq analysis also indicated regulation of several pathways related to HIF-1α and VEGF such as NF-kap-paB, PDGFb and Ang/Tie2 signaling, as reported previously for RNAseq of brain microvessels from experimental stroke and glioma models [37,16]. In the current meningitis data set, we observe an increase in angiopoietin 2 (Ang-2) and a decrease in Tie2 as well as protein tyrosine phosphatase receptor type B (PTPRB; one of the top down-regulated genes).…”
Section: Discussionsupporting
confidence: 80%
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“…RNAseq analysis also indicated regulation of several pathways related to HIF-1α and VEGF such as NF-kap-paB, PDGFb and Ang/Tie2 signaling, as reported previously for RNAseq of brain microvessels from experimental stroke and glioma models [37,16]. In the current meningitis data set, we observe an increase in angiopoietin 2 (Ang-2) and a decrease in Tie2 as well as protein tyrosine phosphatase receptor type B (PTPRB; one of the top down-regulated genes).…”
Section: Discussionsupporting
confidence: 80%
“…6 d). Several genes known to be regulated by HIF-1α, such as angiopoietin2, Tie2, PTPRB that we reported previously for their role in BBB function in ischemic stroke and brain tumors [ 27 , 37 , 16 ], were dysregulated in the infected mice. Additionally, several BBB junctional genes such as occludin, claudin-5, and ZO-1 were found to be downregulated indicating a BBB breakdown (Fig.…”
Section: Resultsmentioning
confidence: 74%
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“…Thus, the NVU consists of neurons, astrocytes, oligodendrocytes, microglia, the vasculature with its endothelium, and other cell types (Lo et al, 2003;del Zoppo, 2009del Zoppo, , 2010Iadecola, 2017). Over time, multiple ischemia-associated affections of NVU components were detected (e.g., Härtig et al, 2009;Michalski et al, 2010Michalski et al, , 2018Aleithe et al, 2019;Mages et al, 2019;Kestner et al, 2020). Furthermore, the blood-brain barrier (BBB) attracted interest as a highly dynamic part of the NVU (Yang et al, 2019).…”
Section: Introductionmentioning
confidence: 99%